Scientific data/documents play a significant role in academic research and industrial applications. In the era of information fusion, building knowledge and content management systems is necessary, particularly in multidisciplinary and interdisciplinary research. This paper discusses an overview about the impact of XML in knowledge and content management systems in science and technology; extends to the integration and implementation including the discussions of infrastructures, methodologies, some typical examples in case studies; finally, it ends with future research and development in a new challenge in information and knowledge engineering. It concluded that XML will make significant contributions to the next generation in information processing for scientific content management systems.