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Number of items: 182.

2014

Motara, Hasina, Mistry, Dharmit, Brown, David R., Cryan, R.A., Nigen, Michaël and Page, Michael I. (2014) pH and basicity of ligands control the binding of metal-ions to B. cereus B1 β-lactamase. Chemical Science, 5 (8). pp. 3120-3129. ISSN 2041-6520

Colivicchi , Stefanini C, Corte, Laura Della, Ward, Roberta J., de Witte, Philippe, Lallemand, Frederic, Hemmings, Karl, Pittard, A., Page, Michael I., Nayak, K. and Dexter, D. T. (2014) Ethane-β-Sultam Modifies the Activation of the Innate Immune System Induced by Intermittent Ethanol Administration in Female Adolescent Rats. Journal of Alcoholism & Drug Dependence, 2 (2). p. 150. ISSN 2329-6488

Sun, Haifeng, Page, Michael I., Atherton, John H. and Hall, Alan (2014) Kinetics of the conversion of methyl benzoate to benzamide by the alumina catalysed reaction with liquid ammonia at 120 °C. Catalysis Science & Technology. ISSN 2044-4753 (In Press)

2013

Mistry, Darmit, Powles, Nicholas and Page, Michael I. (2013) Unusual stability and carbon acidity of a dicationic carbon species. The Journal of Organic Chemistry, 78 (21). pp. 10732-10736. ISSN 0022-3263

Atherton, John H., Page, Michael I. and Sun, Haifeng (2013) Reaction kinetics in liquid ammonia up to 120C: techniques and some solvolysis and substitution reactions. Journal of Physical Organic Chemistry. ISSN 1099-1395

2012

Ji, Pengju, Atherton, John H. and Page, Michael I. (2012) Copper catalysed azide–alkyne cycloaddition (CuAAC) in liquid ammonia. Organic & Biomolecular Chemistry, 10 (39). pp. 7965-7969. ISSN 1477-0520

Ji, Pengju, Atherton, John H. and Page, Michael I. (2012) Copper(I)-Catalyzed Amination of Aryl Halides in Liquid Ammonia. The Journal of Organic Chemistry, 77 (17). pp. 7471-7478. ISSN 0022-3263

Powles, Nicholas, Atherton, John H. and Page, Michael I. (2012) Reactive intermediates in the H-phosphonate synthesis of oligonucleotides. Organic and Biomolecular Chemistry, 10 (30). pp. 5940-5947. ISSN 1477-0539

Fink, Anthony L. and Page, Michael I. (2012) The mechanisms of catalysis by β-lactamases. In: β-Lactamases. Nova Science, New York, USA, pp. 161-198. ISBN 978-1-61324-638-2

Ji, Pengju, Atherton, John H. and Page, Michael I. (2012) Organic reactivity in liquid ammonia. Organic & Biomolecular Chemistry, 10 (30). pp. 5732-5739. ISSN 1477-0520

2011

Ji, Pengju, Powles, Nicholas, Atherton, John H. and Page, Michael I. (2011) Ionization of Carbon Acids in Liquid Ammonia. Organic Letters, 13 (22). pp. 6118-6121. ISSN 1523-7060

Ji, Pengju, Atherton, John H. and Page, Michael I. (2011) The Kinetics and Mechanisms of Aromatic Nucleophilic Substitution Reactions in Liquid Ammonia. The Journal of Organic Chemistry, 76 (9). pp. 3286-3295. ISSN 00223263

Ward, Roberta J., Lallemand, Frederic, de Witte, Philippe, Crichton, Robert R., Piette, Jacques, Tipton, Keith, Hemmings, Karl, Pitard, Arnaud, Page, Michael I. and Corte, Laura Della (2011) Anti-inflammatory actions of a taurine analogue, ethane β-sultam, in phagocytic cells, in vivo and in vitro. Biochemical Pharmacology, 81 (6). pp. 743-751. ISSN 0006-2952

Ji, Pengju, Atherton, John H. and Page, Michael I. (2011) Liquid Ammonia as a Dipolar Aprotic Solvent for Aliphatic Nucleophilic Substitution Reactions. The Journal of Organic Chemistry, 76 (5). pp. 1425-1435. ISSN 00223263

Ward, Roberta J., Lallemand, Frederic, de Witte, Philippe, Chrichton, Robert R, Piette, Jacques, Tipton, Keith, Hemming, Karl, Pitard, Arnaud, Page, Michael I., Corte, Laura Della, Taylor, Deanna and Dexter, David (2011) Anti-inflammatory actions of a taurine analogue - ethane beta-sultam. Biochemical Pharmacology, 81 (6). pp. 743-751. ISSN 0006-2952

2010

Page, Michael I. (2010) Structure and reactivity of β-lactams. In: Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry. Wiley, London, UK, pp. 169-200. ISBN 978-3-527-32102-5

Ji, Pengju, Atherton, John H. and Page, Michael I. (2010) The kinetics and mechanisms of organic reactions in liquid ammonia. Faraday Discussions, 145. pp. 15-25. ISSN 1359-6640

2009

Russell, Mark A., Laws, Andrew P., Atherton, John H. and Page, Michael I. (2009) The kinetics and mechanism of the acid-catalysed detritylation of nucleotides in non-aqueous solution. Organic and Biomolecular Chemistry, 7 (1). pp. 52-57. ISSN 1477-0539

2008

Badarau, Adriana and Page, Michael I. (2008) Loss of enzyme activity during turnover of the Bacillus cereus β-lactamase catalysed hydrolysis of β-lactams due to loss of zinc ion. JBIC Journal of Biological Inorganic Chemistry, 13 (6). pp. 919-928. ISSN 09498257

Russell, Mark A., Laws, Andrew P., Atherton, John H. and Page, Michael I. (2008) The mechanism of the phosphoramidite synthesis of polynucleotides. Organic and Biomolecular Chemistry, 6 (18). pp. 3270-3275. ISSN 1477-0539

Tsang, Wing Y., Ahmed, Naveed, Hemming, Karl and Page, Michael I. (2008) An activated sulfonylating agent that undergoes general base-catalyzed hydrolysis by amines in preference to aminolysis. The Journal of Organic Chemistry, 73 (12). pp. 4504-4512. ISSN 00223263

Mulchande, Jalmira, Guedes, Rita C., Tsang, Wing Y., Page, Michael I., Moreira, Rui and Iley, Jim (2008) Azetidine-2,4-diones (4-Oxo-β-lactams) as Scaffolds for Designing Elastase Inhibitors. Journal of Medicinal Chemistry, 51 (6). pp. 1783-1790. ISSN 0022-2623

Page, Michael I. and Badarau, Adriana (2008) The Mechanisms of Catalysis by Metallo β-Lactamases. Bioinorganic Chemistry and Applications, 2008. pp. 1-14. ISSN 1565-3633

2007

Tsang, Wing Y., Ahmed, Naveed, Hemming, Karl and Page, Michael I. (2007) Reactivity and selectivity in the inhibition of elastase by 3-oxo-β-sultams and in their hydrolysis. Organic and Biomolecular Chemistry, 5 (24). pp. 3993-4000. ISSN 1477-0539

Stirling, Matthew J., Blacker, J. and Page, Michael I. (2007) Chemoenzymatic dynamic kinetic resolution of secondary amines. Tetrahedron Letters, 48 (7). pp. 1247-1250. ISSN 0040-4039

Hanusek, Jifi, Russell, Mark A., Laws, Andrew P. and Page, Michael I. (2007) Evidence for the formation of isothiocyanate during sulphurisation of triphenyl phosphines using xanthane hydride. Tetrahedron Letters, 48 (3). pp. 417-419. ISSN 0040-4039

Blacker, A. John, Stirling, Matthew J. and Page, Michael I. (2007) Catalytic racemisation of chiral amines and application in dynamic kinetic resolution. Organic Process Research and Development, 11 (3). pp. 642-648. ISSN 1083-6160

Hanusek, Jifi, Russell, Mark A., Laws, Andrew P., Jansa, Petr, Atherton, John H., Fettes, Kevin and Page, Michael I. (2007) Mechanism of the sulphurisation of phosphines and phosphites using 3-amino-1,2,4-dithiazole-5-thione (Xanthane Hydride). Organic and Biomolecular Chemistry, 5 (3). pp. 478-484. ISSN 1477-0539

Badarau, Adriana, Damblon, Christian and Page, Michael I. (2007) The activity of the dinuclear cobalt-β-lactamase from bacillus cereus in catalysing the hydrolysis of β-lactams. Biochemical Journal, 401. pp. 197-203. ISSN 0264-6021

Tsang, Wing Y., Ahmed, Naveed and Page, Michael I. (2007) The aminolysis of N-Aroyl β-Lactams occurs by a concerted mechanism. Organic and Biomolecular Chemistry, 5 (3). pp. 485-493. ISSN 1477-0539

2006

Page, Michael I., Tsang, Wing Y. and Ahmed, Naveed (2006) Comparison of the mechanisms of reactions of β-Lactams and β-Sultams including their reactions with some serine enzymes. Journal of Physical Organic Chemistry, 19 (8-9). pp. 446-451. ISSN 1099-1395

Badarau, Adriana and Page, Michael I. (2006) Enzyme deactivation due to metal-ion dissociation during turnover of the cobalt β-lactamase catalysed hydrolysis of β-lactams. Biochemistry, 45 (35). pp. 11012-11020. ISSN 0006-2960

Hemming, Karl, O'Gorman, P.A. and Page, Michael I. (2006) The synthesis of azabicyclo[4.2.1]nonenes by the addition of a cyclopropenone to 4-vinyl substituted 1-azetines-isomers of the homotropane nucleus. Tetrahedron Letters, 47. pp. 425-428. ISSN 0040-4039

Badarau, Adriana and Page, Michael I. (2006) The variation of catalytic efficiency of bacillus cereus metallo- β-lactamase with different active site metal ions. Biochemistry, 45 (35). pp. 10654-10666. ISSN 1520-4995

2005

Tsang, Wing Y., Ahmed, Naveed, Hemming, Karl and Page, Michael I. (2005) Competitive endo- and exo-cyclic C-N fission in the hydrolysis of N-aroyl β-lactams. Canadian Journal of Chemistry, 83 (9). pp. 1432-1439. ISSN 1480-3291

Badarau, Adriana, Llinas, Antonio, Laws, Andrew P., Damblon, Christian and Page, Michael I. (2005) Inhibitors of metallo-β-lactamase generated from β-lactam antibiotics. Biochemistry, 44 (24). pp. 8578-8589. ISSN 1520-4995

Llinas, Antonio, Ahmed, Naveed, Cordaro, Massimiliano, Laws, Andrew P., Frere, Jean-Marie, Delmarcelle, Michael, Silvaggi, Nicholas R., Kelly, Judith A. and Page, Michael I. (2005) The inactivation of bacterial DD-peptidase by β-sultams. Biochemistry, 44 (21). pp. 7738-7746. ISSN 1520-4995

Tsang, Wing Y., Ahmed, Naveed, Harding, Lindsay P., Hemming, Karl, Laws, Andrew P. and Page, Michael I. (2005) Acylation versus sulfonylation in the inhibition of elastase by 3-oxo-beta-sultams. Journal of the American Chemical Society, 127 (25). pp. 8946-8947. ISSN 1520-5126

Tsang, W.Y., Ahmed, Naveed, Hinchliffe, Paul S., Wood, J. Matthew, Harding, Lindsay P., Laws, Andrew P. and Page, Michael I. (2005) Different transition-state structures for the reactions of β-lactams and analogous β-sultams with serine β-lactamases. Journal of the American Chemical Society, 127 (49). pp. 17556-17564. ISSN 1520-5126

2004

Llinas, Antonio, Vilanova, Bartholomew and Page, Michael I. (2004) The thiol catalysed hydrolysis of cephalosporins and possible rate-limiting amine anion expulsion. Journal of Physical Organic Chemistry, 17 (6-7). pp. 521-528. ISSN 1099-1395

Tsang, Wing Y., Dhanda, Anupma, Schofield, Christopher J., Frere, Jean-Marie, Galleni, Moreno and Page, Michael I. (2004) The inhibition of metallo-β-lactamase by thioxo-cephalosporin derivatives. Bioorganic & Medicinal Chemistry Letters, 14 (7). pp. 1737-1739. ISSN 0960-894X

Page, Michael I. (2004) β-sultams-mechanism of reactions and use as inhibitors of serine proteases. Accounts of Chemical Research, 37 (5). pp. 297-303. ISSN 0001-4842

Ahmed, Naveed, Tsang, Wing Y. and Page, Michael I. (2004) Acyl vs Sulfonyl Transfer in N-Acyl β-Sultams and 3-Oxo-β sultams. Organic Letters, 6 (2). pp. 201-203. ISSN 15237060

Llinas, Antonio and Page, Michael I. (2004) Intramolecular general acid catalysis in the aminolysis of β-lactam antibiotics. Organic and Biomolecular Chemistry, 2. pp. 651-654. ISSN 1477-0539

Tsang, Wing Y., Dhanda, Anupma, Schofield, Christopher J. and Page, Michael I. (2004) Kinetics and mechanisms of hydrolysis and aminolysis of thioxocephalosporins. The Journal of Organic Chemistry, 69 (2). pp. 339-344. ISSN 00223263

2003

Page, Michael I., Hinchliffe, Paul S., Wood, J. Matthew, Harding, Lindsay P. and Laws, Andrew P. (2003) Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams. Bioorganic & Medicinal Chemistry Letters, 13 (24). pp. 4489-4492. ISSN 0960-894X

Page, Michael I. (2003) Acyl vs sulfonyl transfer in N-acyl β-sultams and 3-oxo-β-sultams. Organic Letters, 6 (2). pp. 201-203. ISSN 1523-7060

Page, Michael I. (2003) Past times - the efficiency of enzyme catalysis. Biochemist, 25 (4). pp. 52-53. ISSN 0954-982X

Hinchliffe, Paul S., Wood, J. Matthew, Davis, Andrew M., Austin, Rupert P., Beckett, R. Paul and Page, Michael I. (2003) Structure-activity relationships in the inactivation of elastase by β-sultam. Organic and Biomolecular Chemistry, 1 (1). pp. 67-80. ISSN 1477-0539

2002

Wood, J. Matthew and Page, Michael I. (2002) The mechanisms of sulfonyl transfer in strained cyclic sulfonamides. Trends in Heterocyclic Chemistry, 8. pp. 19-34. ISSN 0972-432X

Page, Michael I. (2002) Understanding metallo β-lactamases. American Society for Microbiology News, 68 (5). pp. 217-221.

Sykes, Nicholas O., Macdonald, Simon J.F. and Page, Michael I. (2002) Acylating agents as enzyme inhibitors and understanding their reactivity for drug design. Journal of Medicinal Chemistry, 45 (13). pp. 2850-2856. ISSN 0022-2623

Wood, J. Matthew, Hinchliffe, Paul S., Davis, Andrew M., Austin, Rupert P. and Page, Michael I. (2002) Hydrolysis of a sulfonamide by a novel elimination mechanism generated by carbanion formation in the leaving group. Chemical Communications. pp. 772-773. ISSN 1364-548X

Hadfield, Peter S., Casey, Lorraine A., Galt, Ronald H. B., Vilanova, Bartholomew and Page, Michael I. (2002) Imide and isatin derivatives as β-lactam mimics of β-lactam antibiotics. ARKIVOC, vi. pp. 125-144. ISSN 1424-6376

Seny, Dominique de, Prosperi-Meys, Christelle, Bebrone, Carine, Rossolini, Gian Maria, Page, Michael I., Noel, Phillipe, Frere, Jean-Marie and Galleni, Moreno (2002) Mutational analysis of the two zinc binding sites of the Bacillus cereus 569/H/9 metallo-β-lactamase. Biochemical Journal, 363. pp. 687-696. ISSN 0264-6021

Wood, J. Matthew, Hinchliffe, Paul S., Laws, Andrew P. and Page, Michael I. (2002) Reactivity and the mechanism of reactions of β-sultams with Nucleophiles. Journal of the Chemical Society Perkins Transactions 2. pp. 938-946. ISSN 1364-5471

2001

Bounaga, Sakina, Galleni, Moreno, Laws, Andrew P. and Page, Michael I. (2001) Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase. Bioorganic & Medicinal Chemistry Letters, 9 (2). pp. 503-507. ISSN 0960-894X

Hinchliffe, Paul S., Wood, J. Matthew, Davis, Andrew M., Austin, Rupert P., Beckett, Paul R. and Page, Michael I. (2001) Unusual steric effects in sulfonyl transfer reactions. Perkin Transactions 2. pp. 1503-1505. ISSN 1472-779X

Slater, Martin J., Laws, Andrew P. and Page, Michael I. (2001) The relative catalytic efficiency of β-lactamase catalysed acyl and phosphyl transfer. Bioorganic Chemistry, 29. pp. 77-95. ISSN 0045-2068

Beardsell, Mark, Hinchliffe, Paul S., Wood, J. Matthew, Wilmouth, Rupert C., Schofield, Christopher J. and Page, Michael I. (2001) β-sultams - a novel class of serine protease inhibitors. Chemical Communications. pp. 497-498. ISSN 1364-548X

2000

Allin, Steven M., Vaidya, Darshan G., Page, Michael I. and Slawin, Alexandra M.Z. (2000) Highly diastereoselective synthesis of 2,3-dihydro-9bH- thiazolo[2,3-a]isoindolin-5-ones (00-2016CP). A R K I V O C, 2000. pp. 151-157. ISSN 1551-7004

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (2000) Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives. Journal of the Chemical Society Perkin Transactions 1 (11). pp. 1715-1721. ISSN 14727781

Page, Michael I. and Laws, Andrew P. (2000) The Chemical Reactivity of β-Lactams, β-Sultams and β-Phospholactams. Tetrahedron, 56 (31). pp. 5631-5637. ISSN 0040-4020

Allin, Steven M., Vaidya, Darshan G., Page, Michael I., Slawin, Alexandra M.Z. and Smith, Tim (2000) Highly diastereoselective synthesis and template manipulation of the thiazolo[2,3-a]isoindolin-1-one ring system. Tetrahedron Letters, 41 (13). pp. 2219-2222. ISSN 0040-4039

Baxter, Nicholas J., Rigoreau, Laurent J.M., Laws, Andrew P. and Page, Michael I. (2000) Reactivity and Mechanism in the Hydrolysis of β-Sultams. Journal of the American Chemical Society, 122 (14). pp. 3375-3380. ISSN 1520-5126

Breytenbach, Jaco C., van Dyk, Sandra, van den Heever, Ilse, Allin, Steven M., Hodkinson, Claire C., Northfield, Christopher J. and Page, Michael I. (2000) Synthesis and antimicrobial activity of some isoindolin-1-ones derivatives. Bioorganic & Medicinal Chemistry Letters, 10 (15). pp. 1629-1635. ISSN 0960894X

Llinás, Antonio, Donoso, Josefa, Vilanova, Bartholomew, Frau, Juan, Munoz, Francisco and Page, Michael I. (2000) Thiol-catalysed hydrolysis of benzylpenicillin. Journal of the Chemical Society Perkin Transactions 2 (7). pp. 1521-1525. ISSN 1472779X

1999

Page, Michael I. (1999) The Reactivity of b-Lactams, the Mechanism of Catalysis and the Inhibition of b-Lactamases. Current Pharmaceutical Design, 5 (11). pp. 895-913. ISSN 1381-6128

Rhazi, Noureddine, Page, Michael I. and Frere, Jean-Marie (1999) Peptidase activity of b-lactamases. Biochemical Journal, 341 (2). pp. 409-413. ISSN 0264-6021

Baxter, Nicholas J., Laws, Andrew P., Rigoreau, Laurent J. H. and Page, Michael I. (1999) General acid catalysed hydrolysis of β-sultams involves nucleophilic catalysis. Chemical Communications (23). pp. 2401-2402. ISSN 1359-7345

Barker, C.V., Page, Michael I., Korn, Stewart R. and Monteith, Michael (1999) Esterase catalysed enantioselective ring closure. Chemical Communications (8). pp. 721-722. ISSN 1359-7345

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1999) A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives. Tetrahedron Letters, 40 (1). pp. 143-146. ISSN 0040-4039

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1999) A new approach to the synthesis of non-racemic isoindolin-1-one derivatives. Tetrahedron Letters, 40 (1). pp. 141-142. ISSN 0040-4039

1998

Llinas, Antonio, Vilanova, Bartolomé, Frau, Juan, Munoz, Francisco, Donoso, Josefa and Page, Michael I. (1998) Chemical Reactivity of Penicillins and Cephalosporins. Intramolecular Involvement of the Acyl-Amido Side Chain. The Journal of Organic Chemistry, 63 (24). pp. 9052-9060. ISSN 0022-3263

Beard, Timothy M. and Page, Michael I. (1998) Enantioselective biotransformations using rhodococci. Antonie van Leeuwenhoek, 74 (1/3). pp. 99-106. ISSN 0003-6072

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1998) A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction. Tetrahedron Letters, 39 (27). pp. 4905-4908. ISSN 0040-4039

Page, Michael I. and Laws, Andrew P. (1998) The mechanism of catalysis and the inhibition of β-lactamases. Chemical Communications (16). pp. 1609-1617. ISSN 1359-7345

Bounaga, Sakina, Laws, Andrew P., Galleni, Moreno and Page, Michael I. (1998) The mechanism of catalysis and the inhibition of the Bacillus cereus zinc-dependent b-lactamase. Biochemical Journal, 331 (3). pp. 703-711. ISSN 0264-6021

Heathcote, David M., Atherton, John H., De Boos, Gareth A. and Page, Michael I. (1998) Kinetics of ionisation of 3-phenylcoumaran-2-one and reprotonation of the resulting carbanion. Journal of the Chemical Society, Perkin Transactions 2 (3). pp. 541-546. ISSN 1472-779X

Heathcote, David M., De Boos, Gareth A., Atherton, John H. and Page, Michael I. (1998) Mechanism of hydrolysis of coumaran-2-ones. Journal of the Chemical Society, Perkin Transactions 2 (3). pp. 535-540. ISSN 1472-779X

1997

Baxter, Nicholas J. and Page, Michael I. (1997) Evidence for a trigonal bipyramidal intermediate during nucleophilic substitution at a sulfonyl centre and for a sulfonylium cation in the acid catalysed reaction. Chemical Communications (21). pp. 2037-2038. ISSN 1359-7345

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1997) A highly diastereoselective synthesis of tricyclic lactams and their application as novel N-acyl iminium ion precursors in the synthesis of isoindolinone derivatives. Tetrahedron Letters, 38 (20). pp. 3627-3630. ISSN 0040-4039

Hadfield, Peter S., Galt, Ronald H. B., Sawyer, Yvonne, Layland, Nicola J. and Page, Michael I. (1997) An unexpected Mitsunobu reaction. A direct route to the 2,5-diazabicyclo[2.2.1]heptan-3-one skeleton as a γ-lactam mimic of β-lactam antibiotics. Journal of the Chemical Society, Perkin Transactions 1 (4). pp. 503-509. ISSN 1472-7781

1996

Baxter, Nicholas J., Laws, Andrew P., Rigoreau, Laurent and Page, Michael I. (1996) The hydrolytic reactivity of B-sultams. Journal of the Chemical Society, Perkin Transactions 2 (11). p. 2245. ISSN 1472-779X

Laws, Andrew P. and Page, Michael I. (1996) The chemistry and structure-activity relationships of C3-quaternary ammonium cephem antibiotics. Journal of Chemotherapy, 8. pp. 7-22. ISSN 1120-009X

1995

Page, Michael I., Vilanova, Bartolome and Layland, Nicola J. (1995) pH Dependence of and kinetic solvent isotope effects on the methanolysis and hydrolysis of .beta.-lactams catalyzed by class C .beta.-lactamase. Journal of the American Chemical Society, 117 (49). pp. 12092-12095. ISSN 0002-7863

Layland, Nicola J., Laws, Andrew P., Vilanova, Bartolomé and Page, Michael I. (1995) Penicillin 3-aldehyde is a good substrate and not an inhibitor of ?-lactamases A and C. Journal of the Chemical Society, Perkin Transactions 2 (5). pp. 869-870. ISSN 1472-779X

Page, Michael I., Laws, Andrew P., Slater, Martin J. and Stone, J.R. (1995) Reactivity of β-lactams and phosphonamidates and reactions with β-lactamase. Pure and Applied Chemistry, 67 (5). pp. 711-717. ISSN 0033-4545

1994

Barton, Patrick, Laws, Andrew P. and Page, Michael I. (1994) Structure-activity relationships in the esterase-catalysed hydrolysis and transesterification of esters and lactones. Journal of the Chemical Society, Perkin Transactions 2 (9). pp. 2021-2029. ISSN 1472-779X

Laws, Andrew P., Stone, J.R. and Page, Michael I. (1994) Large rate enhancement for the hydrolysis of a four-membered ring phosphonamidate. Chemical Communications (10). pp. 1223-1224. ISSN 1359-7345

1993

Barton, Patrick and Page, Michael I. (1993) The esterase catalysed resolution of lactones and spirodilactone. Journal of the Chemical Society, Perkin Transactions 2 (12). pp. 2317-2318. ISSN 1472-779X

Laws, Andrew P., Page, Michael I. and Slater, Martin J. (1993) The mechanism of reactions catalysed by the serine β-lactamases. Bioorganic & Medicinal Chemistry Letters, 3 (11). pp. 2317-2322. ISSN 0960-894X

Page, Michael I. (1993) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1993 . John Wiley & Sons, pp. 1-16. ISBN 9780471953371

Casey, Lorraine A., Galt, Ronald H. B. and Page, Michael I. (1993) The mechanisms of hydrolysis of the ?-lactam isatin and its derivatives. Journal of the Chemical Society, Perkin Transactions 2 (1). pp. 23-28. ISSN 1472-779X

Laws, Andrew P., Layland, Nicola J., Proctor, David G. and Page, Michael I. (1993) The roles of the carboxy group in ?-lactam antibiotics and lysine 234 in ?-lactamase I. Journal of the Chemical Society, Perkin Transactions 2 (1). pp. 17-21. ISSN 1472-779X

1992

Barton, Patrick and Page, Michael I. (1992) The resolution of racemic 1,2-diols by the esterase catalysed hydrolysis of the corresponding cyclic carbonate. Tetrahedron, 48 (36). pp. 7731-7734. ISSN 0040-4020

Page, Michael I. (1992) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1992 . John Wiley & Sons, pp. 1-15. ISBN 9780471942245

Page, Michael I. (1992) Structure-activity relationships : chemical. In: The chemistry of (beta) lactams. Blackie Academic and Professional, London, pp. 79-100. ISBN 9780751400618

Page, Michael I. (1992) The mechanisms of reactions of(beta)lactams. In: The chemistry of Beta lactams. Blackie Academic and Professional, London, pp. 129-147. ISBN 9780751400618

1991

Davis, Andrew M., Proctor, Philip and Page, Michael I. (1991) Alcohol-catalysed hydrolysis of benzylpenicillin. Journal of the Chemical Society, Perkin Transactions 2 (8). pp. 1213-1217. ISSN 1472-779X

Davis, Andrew M., Jones, Mark and Page, Michael I. (1991) Thiazolidine ring opening in penicillin derivatives. Part 1. Imine formation. Journal of the Chemical Society, Perkin Transactions 2 (8). pp. 1219-1223. ISSN 1472-779X

Davis, Andrew M., Layland, Nicola J., Page, Michael I., Martin, Frances and O'Ferrall, Rory More (1991) Thiazolidine ring opening in penicillin derivatives. Part 2. Enamine formation. Journal of the Chemical Society, Perkin Transactions 2 (8). pp. 1225-1229. ISSN 1472-779X

Page, Michael I. (1991) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1991 . John Wiley & Sons, pp. 1-20. ISBN 9780471937944

Page, Michael I. (1991) The Energetics of Intramolecular Reactions and Enzyme Catalysis. Philosophical Transactions of the Royal Society B: Biological Sciences, 332 (1263). pp. 149-156. ISSN 0962-8436

Jones, Mark and Page, Michael I. (1991) An esterase with ?-lactamase activity. Chemical Communications (5). pp. 316-317. ISSN 1359-7345

1990

Davies, Karen J. and Page, Michael I. (1990) Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins. Chemical Communications (20). pp. 1448-1450. ISSN 1359-7345

Page, Michael I. (1990) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1990 . John Wiley & Sons, pp. 1-18. ISBN 9780471931034

Page, Michael I., Webster, Philip S. and Ghosez, Leon (1990) The hydrolysis of azetidinyl amidinium salts. Part 1. The unimportance of strain release in the four-membered ring. Journal of the Chemical Society, Perkin Transactions 2 (5). pp. 805-811. ISSN 1472-779X

Page, Michael I., Webster, Philip S. and Ghosez, Leon (1990) The hydrolysis of azetidinyl amidinium salts. Part 2. Substituent effects, buffer catalysis, and the reaction mechanism. Journal of the Chemical Society, Perkin Transactions 2 (5). pp. 813-823. ISSN 1472-779X

Page, Michael I. and Laws, Andrew P. (1990) Molecular recognition in beta lactamases. In: Molecular mechanisms in bioorganic processes. Royal Society of Chemistry, pp. 319-330. ISBN 9780851869469

1989

Laws, Andrew P. and Page, Michael I. (1989) The effect of the carboxy group on the chemical and ?-lactamase reactivity of ?-lactam antibiotics. Journal of the Chemical Society, Perkin Transactions 2 (10). pp. 1577-1581. ISSN 1472-779X

Page, Michael I. (1989) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1989 . John Wiley & Sons, pp. 1-20. ISBN 9780471928256

Jones, Mark, Buckwell, Stephen C., Page, Michael I. and Wrigglesworth, Roger (1989) A reversible inhibitor of ?-lactamase I from Bacillus cereus. Chemical Communications (2). pp. 70-71. ISSN 1359-7345

1988

Buckwell, Stephen C., Page, Michael I., Longridge, Jethro L. and Waley, Stephen G. (1988) Hydrolysis of 3-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ion. Journal of the Chemical Society, Perkin Transactions 2 (10). pp. 1823-1827. ISSN 1472-779X

Buckwell, Stephen C., Page, Michael I. and Longridge, Jethro L. (1988) Hydrolysis of 6-alkyl penicillins catalysed by ?-lactamase I from Bacillus cereus and by hydroxide ion. Journal of the Chemical Society, Perkin Transactions 2 (10). pp. 1809-1813. ISSN 1472-779X

Buckwell, Stephen C., Page, Michael I., Waley, Stephen G. and Longridge, Jethro L. (1988) Hydrolysis of 7-substituted cephalosporins catalysed by ?-lactamases I and II from Bacillus cereus and by hydroxide ion. Journal of the Chemical Society, Perkin Transactions 2 (10). pp. 1815-1821. ISSN 1472-779X

Page, Michael I. (1988) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1988 . John Wiley & Sons, pp. 1-22. ISBN 9780471920298

Page, Michael I. (1988) Energy differences and their relevance to enzyme and intramolecular catalysis. Journal of Molecular Catalysis A: Chemical, 47. pp. 241-253. ISSN 1381-1169

Page, Michael I., Webster, Philip S., Ghosez, Leon and Bogden, S (1988) The ease of C-N bond fission in azetidine derivatives. Actualite Chimique, L'. pp. 272-276. ISSN 0151-9093

1987

Page, Michael I. (1987) The Mechanisms of Reactions of β-Lactam Antibiotics. In: Advances in Physical Organic Chemistry Volume 23. Academic Press, pp. 165-270. ISBN 9780120335237

Page, Michael I. (1987) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series . John Wiley & Sons, pp. 1-27. ISBN 9780471920786

Page, Michael I. (1987) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1987 . John Wiley & Sons, pp. 1-27. ISBN 9780471920786

Sheldrick, B., Akrigg, D., Page, Michael I. and Cox, Geoffrey (1987) Structures of carbocyclic analogues of penicillin. 2. N-(3,4-Dihydroxy-7-oxobicyclo[3.2.0]hept-6-yl)succinimide. Acta Crystallographica Section C Crystal Structure Communications, 43 (3). pp. 594-595. ISSN 0108-2701

Sheldrick, B., Akrigg, D., Page, Michael I. and Cox, Geoffrey (1987) Structures of carbocyclic analogues of penicillin. 3. N-(Bicyclo[3.2.0]hept-2-ene-6-spiro-2'-dioxolane-7-yl)phthalimide. Acta Crystallographica Section C Crystal Structure Communications, 43 (3). pp. 595-597. ISSN 0108-2701

Page, Michael I., Webster, Philip S., Bogdan, S., Tremerie, B. and Ghosez, Leon (1987) Ease of C-N bond cleavage in four-membered rings. Chemical Communications (5). pp. 318-319. ISSN 1359-7345

1986

Buckwell, Stephen C., Page, Michael I. and Longridge, Jethro L. (1986) Equilibria between enamine and B-unsaturated imine in cephalosporin hydrolysis. Chemical Communications (13). pp. 1039-1040. ISSN 1359-7345

Page, Michael I. (1986) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1986 . John Wiley & Sons, pp. 1-27. ISBN 9780471917298

Page, Michael I., Render, David and Bernath, Gabor (1986) Stereochemical studies. Part 112. Geometrical dependence of intramolecular catalysis in the hydrolysis and aminolysis of aryl esters. Journal of the Chemical Society, Perkin Transactions 2 (6). pp. 867-871. ISSN 1472-779X

Agathocleous, D., Cox, Graham and Page, Michael I. (1986) Stereochemistry and ring opening of a carbocyclic analogue of a 1-oxapenam. Tetrahedron Letters, 27 (14). pp. 1631-1634. ISSN 0040-4039

1985

Davis, Andrew M. and Page, Michael I. (1985) Opening of the thiazolidine ring of penicillin derivatives. Chemical Communications (23). pp. 1702-1704. ISSN 1359-7345

Sheldrick, B., Akrigg, D., Page, Michael I. and Agathocleous, D. (1985) Structure of a carbocyclic oxapenam analogue. Acta Crystallographica Section C Crystal Structure Communications, 41 (12). pp. 1816-1817. ISSN 0108-2701

Sheldrick, B., Akrigg, D., Page, Michael I. and Agathocleous, D. (1985) Structure of a carbocyclic analogue of penicillin. Acta Crystallographica Section C Crystal Structure Communications, 41 (6). pp. 942-944. ISSN 0108-2701

1984

Davis, Andrew M., Page, Michael I., Mason, Stephen C. and Watt, Ian (1984) The effective concentration of a hydride transfer reaction. Chemical Communications (24). pp. 1671-1672. ISSN 1359-7345

Sheldrick, B., Akrigg, D., Page, Michael I. and Agathocleous, D. (1984) N-{(1R*,5S*,7R*)-6-Oxobicyclo[3.2.0]hept-2-en-7-yl}phthalimide, C15H11NO3. Acta Crystallographica Section C Crystal Structure Communications, 40 (7). pp. 1217-1219. ISSN 0108-2701

Page, Michael I. (1984) Chapter 1 The energetics and specificity of enzyme—substrate interactions. In: New Comprehensive Biochemistry. New Comprehensive Biochemistry, 6 . Elsevier BV, pp. 1-54. ISBN 9780444805041

Page, Michael I. (1984) Chapter 7 The mechanisms of chemical catalysis used by enzymes. In: New Comprehensive Biochemistry. New Comprehensive Biochemistry, 6 . Elsevier BV, pp. 229-269. ISBN 9780444805041

Page, Michael I. and Proctor, Philip (1984) Mechanism of .beta.-lactam ring opening in cephalosporins. Journal of the American Chemical Society, 106 (13). pp. 3820-3825. ISSN 0002-7863

Page, Michael I. and Crombie, D.A. (1984) Reactions in macromolecular systems. In: Macromolecular Chemistry. Royal Society of Chemistry, pp. 351-374. ISBN 9780-851868769

Page, Michael I. (1984) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1984 . John Wiley & Sons, pp. 1-32. ISBN 9780471907978

Page, Michael I. (1984) The mechanisms of reactions of .beta.-lactam antibiotics. Accounts of Chemical Research, 17 (4). pp. 144-151. ISSN 0001-4842

1983

Page, Michael I. (1983) Reactions of Aldehydes and Ketones and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1983 . John Wiley & Sons, pp. 1-32. ISBN 9780471905035

1982

Proctor, Philip, Gensmantel, Nigel P. and Page, Michael I. (1982) The chemical reactivity of penicillins and other b-lactam antibiotics. Journal of the Chemical Society, Perkin Transactions 2 (9). pp. 1185-1192. ISSN 1472-779X

Crombie, D.A. and Page, Michael I. (1982) Reactions in macromolecular systems. In: Macromolecular Chemistry. Macromolecular Chemistry, 2 . Royal Society of Chemistry, pp. 322-346. ISBN 9780851868660

Page, Michael I. (1982) Reactions of Aldehydes and Ketones and Their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1982 . John Wiley & Sons, pp. 1-17. ISBN 9780471902027

Gensmantel, Nigel P. and Page, Michael I. (1982) The effect of increasing the hydrophobicity of penicillin on its micelle-catalysed hydrolysis. Journal of the Chemical Society, Perkin Transactions 2 (2). pp. 155-159. ISSN 1472-779X

Gensmantel, Nigel P. and Page, Michael I. (1982) The micelle-catalysed hydrolysis of benzylpenicillin. Journal of the Chemical Society, Perkin Transactions 2 (2). pp. 147-153. ISSN 1472-779X

1981

Page, Michael I. (1981) Reactions of Aldehydes and Ketones and Their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1981 . John Wiley & Sons, pp. 1-21. ISBN 9780471104599

1980

Gosney, Alan P. and Page, Michael I. (1980) The mechanism of nitrosation of 4-nitrophenol with aqueous nitrous acid. Journal of the Chemical Society, Perkin Transactions 2 (12). pp. 1783-1787. ISSN 1472-779X

Gensmantel, Nigel P., Proctor, Philip and Page, Michael I. (1980) Metal-ion catalysed hydrolysis of some ?-lactam antibiotics. Journal of the Chemical Society, Perkin Transactions 2 (11). pp. 1725-1732. ISSN 1472-779X

Page, Michael I. (1980) Transition states, standard states and enzymic catalysis. International Journal of Biochemistry, 11 (5). pp. 331-335. ISSN 1357-2725

Morris, Jeffrey J. and Page, Michael I. (1980) Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide. Some comments on the mechanism of catalysis by serine proteases. Journal of the Chemical Society, Perkin Transactions 2 (7). pp. 1131-1136. ISSN 1472-779X

Morris, Jeffrey J. and Page, Michael I. (1980) Hydroxy-group participation in the hydrolysis of amides and its effective concentration in the absence of strain effects. Journal of the Chemical Society, Perkin Transactions 2 (4). pp. 679-684. ISSN 1472-779X

Morris, Jeffrey J. and Page, Michael I. (1980) Structure-reactivity relationships and the mechanism of general base catalysis in the hydrolysis of a hydroxy-amide. Concerted breakdown of a tetrahedral intermediate. Journal of the Chemical Society, Perkin Transactions 2 (4). pp. 685-692. ISSN 1472-779X

Morris, Jeffrey J. and Page, Michael I. (1980) Buffer catalysis in the hydrazinolysis of benzylpenicillin. Journal of the Chemical Society, Perkin Transactions 2 (1). pp. 220-224. ISSN 1472-779X

Morris, Jeffrey J. and Page, Michael I. (1980) Intra- and inter-molecular catalysis in the aminolysis of benzylpenicillin. Journal of the Chemical Society, Perkin Transactions 2 (1). pp. 212-219. ISSN 1472-779X

1979

Page, Michael I. (1979) The principles of enzymatic catalysis. International Journal of Biochemistry, 10 (6). pp. 471-476. ISSN 1357-2725

Martin, Anthony F., Morris, Jeffrey J. and Page, Michael I. (1979) Intramolecular general acid catalysis in the aminolysis of benzylpenicillin. A preferred direction of nucleophilic attack. Chemical Communications (6). pp. 298-299. ISSN 1359-7345

Gensmantel, Nigel P. and Page, Michael I. (1979) The aminolysis of penicillin derivatives. Rate constants for the formation and breakdown of the tetrahedral addition intermediate. Journal of the Chemical Society, Perkin Transactions 2 (2). pp. 137-142. ISSN 1472-779X

1978

Morris, Jeffrey J. and Page, Michael I. (1978) Intramolecular nucleophilic and general acid catalysis in the hydrolysis of an amide. Chemical Communications (14). p. 591. ISSN 1359-7345

Gensmantel, Nigel P. and Page, Michael I. (1978) A tetrahedral intermediate in the aminolysis of benzylpenicillin. Chemical Communications (9). pp. 374-375. ISSN 1359-7345

Gensmantel, Nigel P., Gowling, Eric W. and Page, Michael I. (1978) Metal ion catalysis in the aminolysis of penicillin. Journal of the Chemical Society, Perkin Transactions 2 (4). pp. 335-342. ISSN 1472-779X

1977

Page, Michael I. (1977) Entropy, Binding Energy, and Enzymic Catalysis. Angewandte Chemie International Edition, 16 (7). pp. 449-459. ISSN 1433-7851

1976

Page, Michael I. (1976) Binding energy and enzymic catalysis. Biochemical and Biophysical Research Communications, 72 (2). pp. 456-461. ISSN 0006-291X

Martin, Anthony F., Morris, Jeffrey J. and Page, Michael I. (1976) Intra-and inter-molecular general base catalysis in the aminolysis of benzylpenicillin. Chemical Communications (13). pp. 495-496. ISSN 1359-7345

1975

Page, Michael I. (1975) Reactions of Acids and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1975 . John Wiley & Sons, pp. 23-79. ISBN 9780471018643

1974

Page, Michael I. (1974) Reactions of Acids and their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1974 . John Wiley & Sons, pp. 23-67. ISBN 9780471126935

Jencks, William P. and Page, Michael I. (1974) Orbital steering, entropy, and rate accelerations. Biochemical and Biophysical Research Communications, 57 (3). pp. 887-892. ISSN 0006-291X

Bell, Ronald P., Critchlow, John E. and Page, Michael I. (1974) Ground state and transition state effects in the acylation of a-chymotrypsin in organic solvent-water mixtures. Journal of the Chemical Society, Perkin Transactions 2 (1). pp. 66-70. ISSN 1472-779X

1973

Bell, Ronald P. and Page, Michael I. (1973) Intramolecular general acid catalysis in the halogenation of ketones. Journal of the Chemical Society, Perkin Transactions 2 (12). pp. 1681-1686. ISSN 1472-779X

Page, Michael I. (1973) The energetics of neighbouring group participation. Chemical Society Review, 2 (3). pp. 295-323. ISSN 0306-0012

Page, Michael I. (1973) Reactions of Acids and Their Derivatives. In: Organic Reaction Mechanisms. Organic Reaction Mechanisms Series, 1973 . John Wiley & Sons, pp. 21-60. ISBN 9780471126904

1972

Page, Michael I. and Jencks, William P. (1972) General base and acid catalysis in the hydrazinolysis of acetylimidazole. Journal of the American Chemical Society, 94 (25). pp. 8828-8838. ISSN 0002-7863

Page, Michael I. and Jencks, William P. (1972) Intramolecular general base catalysis in the aminolysis of acetylimidazole and methyl formate by diamines. Journal of the American Chemical Society, 94 (25). pp. 8818-8827. ISSN 0002-7863

Page, Michael I. (1972) Entropic rate accelerations and orbital steering. Biochemical and Biophysical Research Communications, 49 (4). pp. 940-944. ISSN 0006-291X

Capon, Brian and Page, Michael I. (1972) Intramolecular nucleophilic assistance in the reactions of O,O'-benzylidene catechols. Journal of the Chemical Society, Perkin Transactions 2 (14). pp. 2057-2062. ISSN 1472-779X

Fox, John P., Page, Michael I., Satterthwait, Arnold and Jencks, William P. (1972) Nonlinear broensted relation for general acid-base catalysis of aminolysis reactions. Journal of the American Chemical Society, 94 (13). pp. 4729-4732. ISSN 0002-7863

Page, Michael I. and Jencks, William P. (1972) Uncatalyzed aminolysis of acetylimidazole. Limiting product-like transition state for acyl transfer. Journal of the American Chemical Society, 94 (9). pp. 3263-3264. ISSN 0002-7863

Capon, Brian and Page, Michael I. (1972) The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzene (Oo'-benzylidenecatechol) and benzaldehyde diphenyl acetal. Journal of the Chemical Society, Perkin Transactions 2 (5). pp. 522-529. ISSN 1472-779X

Capon, Brian, Page, Michael I. and Sankey, G.H. (1972) The kinetics and mechanism of the hydrolysis of 2,3-(phenylmethylenedioxy)benzoic acid (OO?-benzylidene-2,3-dihydroxybenzoic acid). Journal of the Chemical Society, Perkin Transactions 2 (5). pp. 529-532. ISSN 1472-779X

1971

Page, Michael I. and Jencks, William P. (1971) Entropic Contributions to Rate Accelerations in Enzymic and Intramolecular Reactions and the Chelate Effect. National Academy of Sciences. Proceedings, 68 (8). pp. 1678-1683. ISSN 0027-8424

Capon, Brian and Page, Michael I. (1971) The kinetics and mechanism of the hydrolysis of esters of cis- and trans-2-hydroxycyclopentanecarboxylic acid and 3-hydroxybutyric acid. Journal of the Chemical Society B, physical organic. pp. 741-744. ISSN 1472-779X

1970

Capon, Brian and Page, Michael I. (1970) The mechanism of hydrolysis of 2,3-OO-benzylidene-norbornane-exo-2,-exo-3-diols. Journal of the Chemical Society D: Chemical Communications (21). pp. 1443-1444. ISSN 0577-6171

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