Items where Author is Phillips, Roger

2017

Phillips, Roger M., Hendriks, Hans R, Sweeney, Joseph B., Reddy, Guru and Peters, Godefridus J (2017) Efficacy, pharmacokinetic and pharmacodynamic evaluation of Apaziquone in the treatment of non- muscle invasive bladder cancer. Expert Opinion on Drug Metabolism & Toxicology. ISSN 1742-5255

Allison, Simon J., Sadiq, Maria, Baronou, Efstathia, Cooper, Patricia A., Dunnill, Chris, Georgopoulos, Nikolaos T., Latif, Ayse, Shepherd, Samantha, Shnyder, Steve D., Stratford, Ian J., Wheelhouse, Richard, Willans, Charlotte and Phillips, Roger M. (2017) Preclinical anti-cancer activity and multiple mechanisms of action of a cationic silver complex bearing N-heterocyclic carbene ligands. Cancer Letters. ISSN 0304-3835

Hubbard, Matthew E., Jove, Maria, Loadman, Paul M., Phillips, Roger M., Twelves, Chris J and Smye, Steven W. (2017) Drug delivery in a tumour cord model: a computational simulation. Royal Society Open Science. ISSN 2054-5703

Aradhyula, B.S.R., Kalidasan, M, Gangele, K, Deb, D.K., Shepherd, Samantha L., Phillips, Roger M., Poluri, K.M. and Kollipara, M.R. (2017) Synthesis, Structural and Biological Studies of Some Half-Sandwich d6-Metal Complexes with Pyrimidine-Based Ligand. ChemistrySelect, 2 (6). pp. 2065-2076. ISSN 2365-6549

Basri, Aida M., Lord, Rianne M., Allison, Simon J., Rodríguez-Bárzano, Andrea, Lucas, Stephanie J., Janeway, Felix D., Shepherd, Helena J., Pask, Christopher M., Phillips, Roger M. and McGowan, Patrick Columba (2017) Bis-Picolinamide ruthenium (III) dihalide complexes: dichloride to diiodide exchange generates single trans isomers with high potency and cancer cell selectivity. Chemistry - A European Journal. ISSN 0947-6539

2016

Lord, Rianne M, Crossley, Benjamin D., Hebden, Andrew J., McMullon, Max W., Fisher, Julie, Phillips, Roger M. and McGowan, Patrick C. (2016) β-Diketonate Titanium Compounds Exhibiting High In Vitro Activity and Specific DNA Base Binding. ChemistrySelect, 1 (20). pp. 6598-6605. ISSN 2365-6549

Ayuso, Jose M., Virumbrales-Muñoz, María, Lacueva, Alodia, Lanuza, Pilar M., Checa-Chavarria, Elisa, Botella, Pablo, Fernández, Eduardo, Doblare, Manuel, Allison, Simon J., Phillips, Roger M., Pardo, Julián, Fernandez, Luis J. and Ochoa, Ignacio (2016) Development and characterization of a microfluidic model of the tumour microenvironment. Scientific Reports, 6. p. 36086. ISSN 2045-2322

Adhikari, S., Sutradhar, D., Shepherd, S.L., Phillips, Roger M., Chandra, A.K. and Rao, K.M. (2016) Synthesis, structural, DFT calculations and biological studies of rhodium and iridium complexes containing azine Schiff-base ligands. Polyhedron, 117. pp. 404-414. ISSN 0277-5387

Palepu, Narasinga Rao, Adhikari, Sanjay, Premkumar, Richard J, Verma, Akalesh K, Shepherd, Samantha L, Phillips, Roger M, Kaminsky, Werner and Kollipara, Mohan Rao (2016) Half‐sandwich ruthenium, rhodium and iridium complexes featuring oxime ligands: Structural studies and preliminary investigation of in vitro and in vivo anti‐tumour activities. Applied Organometallic Chemistry. ISSN 0268-2605

Adhikari, S., Palepu, N.R., Sutradhar, D., Shepherd, S.L., Phillips, R.M., Kaminsky, W, Chandra, A.K. and Kollipara, M.R. (2016) Neutral and cationic half-sandwich arene ruthenium, Cp*Rh and Cp*Ir oximato and oxime complexes: Synthesis, structural, DFT and biological studies. Journal of Organometallic Chemistry, 820. pp. 70-81. ISSN 0022-328X

Phillips, Roger M. (2016) Targeting the hypoxic fraction of tumours using hypoxia activated prodrugs. Cancer Chemotherapy and Pharmacology, 77 (3). pp. 441-457. ISSN 0344-5704

Lucas, Stephanie. J., Lord, Rianne M., Basri, Aida M., Allison, Simon J., Phillips, Roger M., Blacker, A. John and McGowan, Patrick C. (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes. Dalton Transactions (16). ISSN 1477-9226

Javid, Farideh A., Phillips, Roger M., Afshinjavid, S., Verde, Roberta and Ligresti, Alessia (2016) Cannabinoid pharmacology in cancer research: A new hope for cancer patients? European Journal of Pharmacology. ISSN 0014-2999

2015

Kaner, R.A., Allison, Simon J., Faulkner, A.D., Phillips, R.M., Roper, D.I., Shepherd, S.L., Simpson, D.H., Waterfield, N.R. and Scott, P. (2015) Anticancer metallohelices: nanomolar potency and high selectivity. Chemical Science. ISSN 2041-6520

Lord, Rianne M, Hebden, Andrew J, Pask, Christopher M, Henderson, Imogen R, Allison, Simon J., Shepherd, Samantha L, Phillips, Roger M and McGowan, Patrick C (2015) Hypoxia Sensitive Metal β-Ketoiminate Complexes Showing Induced Single Strand DNA Breaks and Cancer Cell Death by Apoptosis. Journal of Medicinal Chemistry, 58 (12). pp. 4940-4953. ISSN 0022-2623

Mohamed, Heba A, Lake, Benjamin RM, Laing, Thomas, Phillips, Roger M and Willans, Charlotte E (2015) Synthesis and anticancer activity of silver(I)– N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine. Dalton Transactions, 44 (16). pp. 7563-7569. ISSN 1477-9226

Rodríguez-Bárzano, A, Lord, RM, Basri, AM, Phillips, Roger, Blacker, AJ and McGowan, PC (2015) Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands. Dalton Transactions, 44 (7). pp. 3265-3270. ISSN 1477-9226

Ramirez, Yulian P, Mladek, Ann C, Phillips, Roger M, Gynther, Mikko, Rautio, Jarkko, Ross, Alonso H, Wheelhouse, Richard T and Sakaria, Jann N (2015) Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth. Molecular Cancer Therapeutics, 14. pp. 111-119. ISSN 1535-7163

2014

Wong, Charng Choon, Periasamy, Nararajan, Sagineedu, Sreenivasa R., Sidik, Shiran, Sumon, Shariful Hasan, Loadman, Paul M., Phillips, Roger M., Lajis, Nordin Haji and Stanslas, Johnson (2014) In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog. Investigational new drugs, 32 (5). pp. 806-814. ISSN 0167-6997

Kalidasan, Mahesh, Forbes, Scott, Mozharivskyj, Yurij, Ahmadi, Maryam, Ahmadihosseini, Zeynab, Phillips, Roger M and Kollipara, Mohan R (2014) Mononuclear half-sandwich cyclic-p-perimeter platinum group metal complexes having bithiazole ligands: Synthesis, molecular and anti- cancer studies. Inorganica Chimica Acta, 421. pp. 349-358. ISSN 0020-1693

Wong, Charng Choon, Sagineedu, Sreenivasa R., Sumon, Shariful Hasan, Sidik, Shiran M., Phillips, Roger M., Lajis, Nordin H. and Stanslas, Johnson (2014) NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide. Environmental Toxicology and Pharmacology, 38 (2). pp. 489-501.

Faulkner, Alan D., Kaner, Rebecca A., Abdallah, Qasem M. A., Clarkson, Guy, Fox, David J., Gurnani, Pratik, Howson, Suzanne E., Phillips, Roger M., Roper, David I., Simpson, Daniel H. and Scott, Peter (2014) Asymmetric triplex metallohelices with high and selective activity against cancer cells. Nature Chemistry, 6 (9). pp. 797-803. ISSN 17554330

Lord, Rianne M., Mannion, James J., Hebden, Andrew J., Nako, Adi E., Crossley, Benjamin D., McMullon, Max W., Janeway, Felix D., Phillips, Roger M. and McGowan, Patrick C. (2014) Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes. ChemMedChem Communications, 9 (6). pp. 1136-1139. ISSN 1860-7179

Allison, Simon J., Knight, J.R.P., Granchi, C., Rani, R., Minutolo, F., Milner, J. and Phillips, R.M. (2014) Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways. Oncogenesis, 3 (e102). pp. 1-11. ISSN 2157-9024

Groh, Christian M., Hubbard, Matthew E., Jones, Pamela F., Loadman, Paul M., Periasamy, Raj, Sleeman, Brain D., Smye, Steven W., Twelves, Chris J. and Phillips, Roger M. (2014) Mathematical and computational models of drug transport in tumours. Interface: Journal of the Royal Society, 11 (94). p. 1173. ISSN 1742-5662

Ahmadi, M., Ahmadihosseini, Z., Allison, Simon J., Begum, S., Rockley, K., Sadiq, M., Chintamaneni, S., Lokwani, R., Hughes, N. and Phillips, R. M. (2014) Hypoxia modulates the activity of a series of clinically approved tyrosine kinase inhibitors. British Journal of Pharmacology, 171 (1). pp. 224-236. ISSN 0007-1188

Almodares, Zahra, Lucas, Stephanie J., Crossley, Benjamin D., Basri, Aida M., Pask, Christopher M., Hebden, Andrew J., Phillips, Roger M. and McGowan, Patrick C. (2014) Rhodium, Iridium, and Ruthenium Half-Sandwich Picolinamide Complexes as Anticancer Agents. Inorganic Chemistry, 53 (2). pp. 727-736. ISSN 0020-1669

2013

Brabec, V, Howson, SE, Kaner, RA, Lord, RM, Malina, J, Phillips, Roger, Abdallah, QMA, McGowan, PC, Rodger, A and Scott, P (2013) Metallohelices with activity against cisplatin-resistant cancer cells; does the mechanism involve DNA binding? Chemical Science, 4 (12). pp. 4407-4416. ISSN 2041-6520

Pletsas, D, Garelnabi, EAE, Li, L, Phillips, Roger and Wheelhouse, RT (2013) Synthesis and Quantitative Structure–Activity Relationship of Imidazotetrazine Prodrugs with Activity Independent of O6-Methylguanine-DNA-methyltransferase, DNA Mismatch Repair and p53. Journal of Medicinal Chemistry, 56 (174). pp. 7120-7132. ISSN 0022-2623

Groome, Nigel M., Elboray, Elghareeb E., Inman, Martyn W., Dondas, H. Ali, Phillips, Roger M., Kilner, Colin and Grigg, Ronald (2013) Carbophilic 3-component cascades: access to complex bioactive cyclopropyl diindolylmethanes. Chemistry - A European Journal, 19 (6). pp. 2180-2184. ISSN 0947-6539

Phillips, Roger M, Hendriks, Hans R and Peters, Godefridus J (2013) EO9 (Apaziquone): from the clinic to the laboratory and back again. British Journal of Pharmacology, 168 (1). pp. 11-18. ISSN 0007-1188

Donnelly, Oliver G, Errington-Mais, Fiona, Steele, Lynette, Hadac, Elizabeth, Jennings, Victoria, Scott, Karen, Peach, Howard, Phillips, Roger M, Bond, Jacquelyn, Pandha, Hardev, Harrington, Kevin, Vile, Richard, Russell, Stephen, Selby, Peter and Melcher, Alan A (2013) Measles virus causes immunogenic cell death in human melanoma. Gene Therapy, 20 (1). pp. 7-15. ISSN 0969-7128

2012

Lucas, Stephanie J, Lord, Rianne M, Wilson, Rachel L, Phillips, Roger M, Sridharan, Visuvanathar and McGowan, Patrick C (2012) Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents. Dalton Transactions, 41 (45). pp. 13800-13802. ISSN 1477-9226

Kazmi, N., Hossain, M.A., Phillips, R.M., Al-Mamum, M.A. and Bass, R. (2012) Avascular tumour growth dynamics and the constraints of protein binding for drug transportation. Journal of Theoretical Biology, 313. pp. 142-152. ISSN 0022-5193

Kazmi, Nabila, Hossain, M.A. and Phillips, Roger M (2012) A hybrid cellular automaton model of solid tumor growth and bioreductive drug transport. IEEE/ACM transactions on computational biology and bioinformatics, 9 (6). pp. 1595-1606. ISSN 1545-5963

Garelnabi, EAE, Pletsas, D, Li, L, Kiakos, K, Karodia, N, Hartley, JA, Phillips, Roger and Wheelhouse, RT (2012) A Strategy for Imidazotetrazine Prodrugs with Anti-cancer Activity Independent of MGMT and MMR. ACS Medicinal Chemistry Letters, 3 (12). pp. 965-968. ISSN 1948-5875

Abdallah, QMA, Phillips, Roger, Johansson, F, Helleday, D, Cosentino, L, Abdel-Rahman, H, Etzad, J, Wheelhouse, RT, Kiakos, K, Bingham, JP, Hartley, JA, Patterson, LH and Pors, K (2012) Minor structural modifications to alchemix influence mechanism of action and pharmacological activity. Biochemical Pharmacology, 83 (11). pp. 1514-1522. ISSN 0006-2952

McMahon, K.M., Volpato, M., Chi, H.Y., Musiwaro, P., Poterlowicz, K., Peng, Y., Scally, A.J., Patterson, L.H., Phillips, Roger M and Sutton, C.W. (2012) Characterization of changes in the proteome in different regions of 3D multicell tumor spheroids. Journal of Proteome Research, 11 (5). pp. 2863-2875.

Monteiro, DCF, Phillips, Roger, Crossley, BD, Fielden, J and Willans, CE (2012) Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands. Dalton Transactions, 41 (13). pp. 3720-3725. ISSN 1477-9226

Qiao, Boling, Kerr, Martin, Groselj, Blaz, Teo, Mark, Knowles, Margaret, Bristow, Robert, Phillips, Roger and Kiltie, Anne (2012) Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination. Cancer Research, 73 (5). pp. 1611-1620. ISSN 00085472

2009

Maurice, HB, Phillips, Roger and Karodia, N (2009) Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer. African Journal of Pharmacy and Pharmacology, 3 (12). pp. 602-610. ISSN ISSN 1996-0816

Shervington, LA, Smith, N, Norman, E, Ward, T, Phillips, Roger and Shervington, A (2009) To determine the cytotoxicity of chlorambucil and one of its nitro-derivatives, conjugated to prasterone and pregnenolone, towards eight human cancer cell-lines. European Journal of Medicinal Chemistry, 44 (7). pp. 2944-2951. ISSN 0223-5234

Jain, A.K., Phillips, Roger M., Scally, A.J., Lenaz, G., Beer, M. and Puri, R. (2009) Response of multiple recurrent TaT1 bladder cancer to intravesical apaziquone (EO9): comparative analysis of tumor recurrence rates. Urology, 73 (5). pp. 1083-1086.

Evans, C.J., Phillips, Roger M., Jones, P.F., Loadman, P.M., Sleeman, B.D., Twelves, C.J. and Smye, S.W. (2009) A mathematical model of doxorubicin penetration through multicellular layers. Journal of Theoretical Biology, 257 (4). pp. 598-608. ISSN 0022-5193

2008

Evans, A., Bates, Victoria, Troy, H., Hewitt, S., Chung, Y.L., Phillips, Roger M, Stubbs, M., Griffiths, J. and Airely, R. (2008) Glut-1 as a therapeutic target: increased chemoresistance and HIF-1-independent link with cell turnover is revealed through COMPARE analysis and metabolomic studies. Cancer Chemotherapy and Pharmacology, 61 (3). pp. 377-393. ISSN 0344-5704

Albertella, Mark R, Loadman, Paul M, Jones, Philip H, Phillips, Roger M, Rampling, Roy, Burnet, Neil, Alcock, Chris, Anthoney, Alan, Vjaters, Egils, Dunk, Chris R, Harris, Peter A, Wong, Alvin, Lalani, Alshad S and Twelves, Chris J (2008) Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study. Clinical cancer research, 14 (4). pp. 1096-1104. ISSN 1078-0432

2007

Volpato, Milene, Abou-Zeid, Nathalie, Tanner, Richard W, Glassbrook, Lee T, Taylor, James, Stratford, Ian J, Loadman, Paul M, Jaffar, Mohammed and Phillips, Roger M (2007) Chemical synthesis and biological evaluation of a NAD(P)H:quinone oxidoreductase-1–targeted tripartite quinone drug delivery system. Molecular Cancer Therapeutics, 6 (12). pp. 3122-3130. ISSN 1535-7163

Seville, S., Phillips, Roger M., Shnyder, S.D. and Wright, C.W. (2007) Synthesis of cryptolepine analogues as potential bioreducible anticancer agents. Bioorganic & Medicinal Chemistry, 15 (19). pp. 6353-6360. ISSN 0968-0896

Volpato, Milene and Phillips, Roger M (2007) Tailoring Targeted Therapy to Individual Patients: Lessons to be Learnt from the Development of Mitomycin C. Cancer genomics and proteomics, 4 (3). pp. 175-186. ISSN 1109-6535,

2006

Puri, R., Palit, V., Loadman, P.M., Flannigan, M., Shah, T. K., Choudry, G.A., Basu, S., Double, J.A., Lenaz, G., Chawla, S., Beer, M., Van Kalken, C., de Boer, R., Beijnen, J.H., Twelves, C.J. and Phillips, Roger M. (2006) Phase I/II pilot study of intravesical apaziquone (EO9) for superficial bladder cancer. Journal of Urology, 176 (4). pp. 1344-1348.

Pavillard, V., Nicolaou, A., Double, J.A. and Phillips, Roger M. (2006) Methionine dependence of tumours: a biochemical strategy for optimizing paclitaxel chemosensitivity in vitro. Biochemical Pharmacology, 71 (6). pp. 772-778. ISSN 0006-2952

2005

Palit, V., Phillips, Roger M., Puri, R., Shah, T. K. and Bibby, M.C. (2005) Expression of HIF-1alpha and Glut-1 in human bladder cancer. Oncology Reports, 14 (4). pp. 909-913. ISSN 1021-335X

Volpato, M., Seargent, J.M., Loadman, P.M. and Phillips, Roger M. (2005) Formation of DNA interstrand cross-links as a marker of Mitomycin C bioreductive activation and chemosensitivity. European Journal of Cancer, 41 (9). pp. 1331-1338. ISSN 0959-8049

Airley, Rachel, Phillips, Roger M., Evans, A.E., Double, J.A., Burger, A.M., Feibig, H.H., West, Catharine M.L. and Stratford, I.J. (2005) Hypoxia-regulated glucose transporter Glut-1 may influence chemosensitivity to some alkylating agents: results of EORTC (First Translational Award) study of the relevance of tumour hypoxia to the outcome of chemotherapy in human tumour-derived xenografts. International journal of oncology, 26 (6). pp. 1477-1484. ISSN 1019-6439

Ferguson, R.E., Jackson, S.M., Stanley, A.J., Joyce, A.D., Harnden, P., Morrison, E.E., Patel, P.M., Phillips, Roger M., Selby, P.J. and Banks, R.E. (2005) Intrinsic chemotherapy resistance to the tubulin-binding antimitotic agents in renal cell carcinoma. International Journal of Cancer, 115 (1). pp. 155-163. ISSN 0020-7136

Onyeibor, O., Croft, S.L., Dodson, H.I., Feiz-Haddad, M., Kendrick, H., Millington, N.J., Parapini, S., Phillips, Roger M., Seville, S., Shnyder, S.D., Taramelli, D. and Wright, C.W. (2005) Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. Journal of Medicinal Chemistry, 48 (7). pp. 2701-2709. ISSN 0022-2623

2004

Phillips, Roger M., Jaffar, M., Maitland, D.J., Loadman, P.M., Shnyder, S.D., Steans, G., Cooper, P.A., Race, A., Patterson, A.V. and Stratford, I.J. (2004) Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs. Biochemical Pharmacology, 68 (11). pp. 2107-2116. ISSN 0006-2952

Basu, S., Brown, J.E., Flannigan, G.M., Gill, J.H., Loadman, P.M., Martin, S.W., Naylor, B., Puri, R., Scally, A.J., Seargent, J.M., Shah, T. K. and Phillips, Roger M. (2004) NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C. International Journal of Oncology, 25 (4). pp. 921-927. ISSN 1019-6439

Basu, S., Brown, J. E., Flannigan, G.M., Gill, J.H., Loadman, P.M., Martin, S.W., Naylor, B., Scally, A.J., Seargent, J.M., Shah, T. K., Puri, R. and Phillips, Roger M. (2004) Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy. International Journal of Cancer, 109 (5). pp. 703-709. ISSN 0020-7136

Pavillard, V., Drbal, A.A., Swaine, D.J., Phillips, Roger M., Double, J.A. and Nicolaou, A. (2004) Analysis of cell-cycle kinetics and sulfur amino acid metabolism in methionine-dependent tumor cell lines; the effect of homocysteine supplementation. Biochemical Pharmacology, 67 (8). pp. 1587-1599. ISSN 0006-2952

Phillips, Roger M., Basu, S., Brown, J.E., Flannigan, G.M., Loadman, P.M., Martin, S.W., Naylor, B., Puri, R. and Shah, T. K. (2004) Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP. International journal of oncology, 24 (4). pp. 1005-1010. ISSN 1019-6439

Phillips, Roger M. and Basu, S. (2004) Biological and Clinical Significance of Polymorphisms in NAD(P)H: Quinone Oxidoreductase 1 (NQO1). Current Pharmacogenomics and Personalized Medicine, 2 (1). pp. 75-82. ISSN 1570-1603

Hall, M.D., Martin, C., Ferguson, D.J., Phillips, Roger M., Hambley, T.W. and Callaghan, R. (2004) Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models. Biochemical Pharmacology, 67 (1). pp. 17-30. ISSN 0006-2952

2003

Suggitt, M., Fearnley, J., Swaine, D.J., Volpato, M., Phillips, Roger M., Bibby, Michael C., Loadman, P.M. and Anderson, D. (2003) Comet assay and flow cytometry analysis of DNA repair in normal and cancer cells treated with known mutagens with different mechanisms of action. Teratogenesis, Carcinogenesis and Mutagenesis, 23 (S2). pp. 13-29. ISSN 1520-6866

Jaffar, M., Phillips, Roger M., Williams, K.J., Mrema, I., Cole, C., Wind, N.S., Ward, T.H., Stratford, I.J. and Patterson, A.V. (2003) 3-substituted-5-aziridinyl-1-methylindole-4,7-diones as NQO1-directed antitumour agents: mechanism of activation and cytotoxicity in vitro. Biochemical Pharmacology, 66 (7). pp. 1199-1206. ISSN 0006-2952

Cowen, Rachel L., Patterson, Adam V., Telfer, Brian A, Airely, Rachel E, Hobbs, Steve, Phillips, Roger M, Jaffar, Mohammed, Stratford, Ian J and Williams, Kaye J (2003) Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts. Molecular Cancer Therapeutics, 2. pp. 901-909. ISSN 1535-7163

Basu, S., Martin, S.W., Phillips, Roger M. and Puri, R. (2003) Obtaining archived pathological material for biomedical research. Lancet, 361 (9366). p. 1394. ISSN 0140-6736

2002

Loadman, Paul M., Bibby, Michael C. and Phillips, Roger M. (2002) Pharmacological approach towards the development of indolequinone bioreductive drugs based on the clinically inactive agent EO9. British Journal of Pharmacology, 137 (5). pp. 701-709. ISSN 0007-1188

Nicholson, K.M., Phillips, Roger M., Shnyder, S.D. and Bibby, M.C. (2002) In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine. European Journal of Cancer, 38 (1). pp. 194-204. ISSN 0959-8049

2001

Phillips, Roger M., Burger, A.M., Fiebig, H.H. and Double, J.A. (2001) Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo. Biochemical Pharmacology, 62 (10). pp. 1371-1377. ISSN 0006-2952

Knowles, H.J. and Phillips, Roger M. (2001) Identification of differentially expressed genes in experimental models of the tumor microenvironment using differential display. Anticancer Research, 21 (4A). pp. 2305-2311. ISSN 0250-7005

Phillips, Roger M. and Ward, T.H. (2001) Influence of extracellular pH on the cytotoxicity and DNA damage of a series of indolequinone compounds. Anticancer Research, 21 (3B). pp. 1795-1801. ISSN 0250-7005

Phillips, Roger M. and Bibby, M.C. (2001) Hollow fiber assay for tumor angiogenesis. Methods in Molecular Medicine, 46. pp. 87-93.

Wright, C.W., Addee-Kyereme, J., Breen, A.G., Brown, J.E., Cox, M.F., Croft, S.L., Gokcek, Y., Kendrick, H., Phillips, Roger M. and Pollet, P.L. (2001) Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. Journal of Medicinal Chemistry, 44 (19). pp. 3187-3194. ISSN 0022-2623

Choudry, G. A., Hamilton Stewart, P. A., Double, J. A., Krul, M. R. L., Naylor, B., Flannigan, G. M., Shah, T. K., Brown, J. E. and Phillips, Roger M. (2001) A novel strategy for NQO1 (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) mediated therapy of bladder cancer based on the pharmacological properties of EO9. British Journal of Cancer, 85 (8). pp. 1137-1146. ISSN 0007-0920

2000

Phillips, Roger M, Burger, Angelika M., Loadman, Paul M., Jarrett, Claire M., Swaine, David J. and Feibig, Heinz Herbert (2000) Predicting Tumor Responses to Mitomycin C on the Basis of DT-Diaphorase Activity or Drug Metabolism by Tumor Homogenates: Implications for Enzyme-directed Bioreductive Drug Development. Cancer Research, 60. pp. 6384-6390. ISSN 0008-5472

Phillips, Roger M., Burger, A.M., Loadman, P.M., Jarrett, Claire M., Swaine, D.J. and Fiebig, H.H. (2000) Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development. Cancer Research, 60 (22). pp. 6384-6390. ISSN 0008-5472

Phillips, Roger M. (2000) AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics. Expert Opinion on Investigational Drugs, 9 (3). pp. 631-638.

Loadman, P.M., Phillips, Roger M., Lim, L.E. and Bibby, M.C. (2000) Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice. Biochemical Pharmacology, 59 (7). pp. 831-837. ISSN 0006-2952

Saunders, M.P., Jaffar, Mohammed, Patterson, A.V., Nolan, J., Naylor, Mark, Phillips, Roger M., Harris, A.L. and Stratford, I.J. (2000) The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions. Biochemical Pharmacology, 59 (8). pp. 993-996. ISSN 0006-2952

1999

Phillips, Roger M., Naylor, M.A., Jaffar, M., Doughty, S.W., Everett, S.A., Breen, A.G., Choudry, G.A. and Stratford, I.J. (1999) Bioreductive activation of a series of indolequinones by human DT-diaphorase: structure-activity relationships. Journal of Medicinal Chemistry, 42 (20). pp. 4071-4080. ISSN 0022-2623

Phillips, Roger M. (1999) Inhibition of DT-diaphorase (NAD(P)H:quinone oxidoreductase, EC 1.6.99.2) by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and flavone-8-acetic acid (FAA): implications for bioreductive drug development. Biochemical Pharmacology, 58 (2). pp. 303-310. ISSN 0006-2952

1998

Phillips, Roger M., Pearce, J., Loadman, Paul M., Bibby, M.C., Cooper, P.A., Swaine, D.J. and Double, J.A. (1998) Angiogenesis in the hollow fiber tumor model influences drug delivery to tumor cells: implications for anticancer drug screening programs. Cancer Research, 58 (23). pp. 5263-5266. ISSN 0008-5472

Phillips, Roger M., Loadman, P.M. and Cronin, B.P. (1998) Evaluation of a novel in vitro assay for assessing drug penetration into avascular regions of tumours. British Journal of Cancer, 77 (12). pp. 2112-2119. ISSN 0007-0920

Jaffar, M., Naylor, M.A., Robertson, N., Lockyer, S.D., Phillips, Roger M., Everett, S.A., Adams, G.E. and Stratford, I.J. (1998) 5-substituted analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en- 1-ol (EO9, NSC 382459) and their regioisomers as hypoxia-selective agents: structure-cytotoxicity in vitro. Anti-Cancer Drug Design, 13 (2). pp. 105-123. ISSN 0266-9536

Phillips, Roger M. (1998) Prospects for bioreductive drug development. Expert Opinion on Investigational Drugs, 7 (6). pp. 905-928.

1997

Nicholson, K.M., Bibby, M.C. and Phillips, Roger M. (1997) Influence of drug exposure parameters on the activity of paclitaxel in multicellular spheroids. European Journal of Cancer, 33 (8). pp. 1291-1298. ISSN 0959-8049

Traver, R.D., Siegel, D., Beall, H.D., Phillips, Roger M., Gibson, N.W., Franklin, W.A. and Ross, D. (1997) Characterization of a polymorphism in NAD(P)H: quinone oxidoreductase (DT-diaphorase). British Journal of Cancer, 75 (1). pp. 69-75. ISSN 0007-0920

Phillips, Roger M. and Clayton, M.R. (1997) Plateau-phase cultures: an experimental model for identifying drugs which are bioactivated within the microenvironment of solid tumours. British Journal of Cancer, 75 (2). pp. 196-201. ISSN 0007-0920

1996

Phillips, Roger M. (1996) Bioreductive activation of a series of analogues of 5-aziridinyl-3-hydroxymethyl-1-methyl-2-[1H-indole-4, 7-dione] prop-beta-en-alpha-ol (EO9) by human DT-diaphorase. Biochemical Pharmacology, 52 (11). pp. 1711-1718. ISSN 0006-2952

Aitken, R.A., Bibby, M.C., Double, J.A., Phillips, Roger M. and Sharma, S.K. (1996) Synthesis and antitumour activity of new derivatives of flavone-8-acetic acid (FAA). Part 1: 6-Methyl derivatives. Archiv der Pharmazie, 329 (11). pp. 489-497.

1994

Phillips, Roger M., de la Cruz, A., Traver, R.D. and Gibson, N.W. (1994) Increased activity and expression of NAD(P)H:quinone acceptor oxidoreductase in confluent cell cultures and within multicellular spheroids. Cancer Research, 54 (14). pp. 3766-3771. ISSN 0008-5472

Ross, D., Beall, H.D., Traver, R.D., Siegel, D., Phillips, Roger M. and Gibson, N.W. (1994) Bioactivation of quinones by DT-diaphorase, molecular, biochemical, and chemical studies. Oncology Research, 6 (10-11). pp. 493-500.

Gibson, N.W., Phillips, Roger M. and Ross, D. (1994) Mitomycin C. Cancer Chemotherapy and Biological Response Modifiers, 15. pp. 51-57. ISSN 0921-4410

1993

Matthew, A.M., Phillips, Roger M., Loadman, P.M. and Bibby, M.C. (1993) Pre-clinical evaluation of a novel chloroethylating agent, Clomesone. British Journal of Cancer, 67 (3). pp. 441-446. ISSN 0007-0920

1992

Woldermariam, T.Z., Fell, A.F., Linley, P.A., Bibby, M.C. and Phillips, Roger M. (1992) Evaluation of the anti-tumour action and acute toxicity of kosins from Hagenia abyssinica. Journal of Pharmaceutical and Biomedical Analysis, 10 (8). pp. 555-560. ISSN 07317085

Phillips, Roger M., Hulbert, P.B., Bibby, M.C., Sleigh, N.R. and Double, J.A. (1992) In vitro activity of the novel indoloquinone EO-9 and the influence of pH on cytotoxicity. British Journal of Cancer, 65 (3). pp. 359-364. ISSN 0007-0920

Aghil, O., Bibby, M.C., Carrington, S.J., Double, J.A., Douglas, K.T., Phillips, Roger M. and Shing, T.K. (1992) Synthesis and cytotoxicity of shikimate analogues. Structure:activity studies based on 1-crotonyloxymethyl-3R,4R,5R-trihydroxycyclohex-2-enone. Anti-Cancer Drug Design, 7 (1). pp. 67-82. ISSN 0266-9536

1991

Bibby, M.C., Phillips, Roger M. and Double, J.A. (1991) The relationship between tissue levels of flavone acetic acid (NSC 347512) and site dependent anti-tumour activity in murine colon tumours. British Journal of Cancer, 63 (4). pp. 541-545. ISSN 0007-0920

Phillips, Roger M., Bibby, M.C., Double, J.A. and Loadman, P.M. (1991) The relationship between the in vitro chemosensitivity of tumor cells and tumor response in vivo in an experimental tumor model. International journal of cell cloning, 9 (2). pp. 144-154.

Bibby, M.C., Phillips, Roger M., Double, J.A. and Pratesi, G. (1991) Anti-tumour activity of flavone acetic acid (NSC 347512) in mice--influence of immune status. British Journal of Cancer, 63 (1). pp. 57-62. ISSN 0007-0920

Bibby, M.C., Double, J.A., Phillips, Roger M. and Quinn, P.K. (1991) Flavone acetic acid: is vascular shutdown the crucial mechanism of action. International Journal of Radiation Biology, 60 (1-2). pp. 395-399.

1990

Phillips, Roger M., Bibby, M.C. and Double, J.A. (1990) A critical appraisal of the predictive value of in vitro chemosensitivity assays. Journal of the National Cancer Institute, 82 (18). pp. 1457-1468. ISSN 1460-2105

1989

Bibby, M.C., Phillips, Roger M. and Double, J.A. (1989) Influence of site on the chemosensitivity of transplantable murine colon tumours to flavone acetic acid (LM975, NSC 347512). Cancer Chemotherapy and Pharmacology, 24 (2). pp. 87-94. ISSN 0344-5704

1988

Phillips, Roger M., Bibby, Michael C. and Double, J.A. (1988) In vitro and in vivo responses of a panel of murine colon tumours to TCNU: a positive correlation. European Journal of Cancer, 24 (8). pp. 1365-1371. ISSN 0959-8049

Phillips, Roger M., Bibby, M.C. and Double, J.A. (1988) Experimental correlations of in vitro drug sensitivity with in vivo responses to ThioTEPA in a panel of murine colon tumours. Cancer Chemotherapy and Pharmacology, 21 (2). pp. 168-172. ISSN 0344-5704

Bibby, M.C., Double, J.A., Phillips, Roger M., Loadman, P.M. and Gummer, J.A. (1988) Experimental anti-tumor effects of flavone acetic acid (LM975). Progress in Clinical and Biological Research, 280. pp. 243-246.

1987

Bibby, M.C., Double, J.A., Phillips, Roger M. and Loadman, Paul M. (1987) Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). British Journal of Cancer, 55 (2). pp. 159-163. ISSN 0007-0920

Bibby, M.C., McDermott, B.J., Double, J.A., Phillips, Roger M., Loadman, Paul M. and Burgess, L. (1987) Influence of the tissue distribution of ThioTEPA and its metabolite, TEPA, on the response of murine colon tumours. Cancer Chemotherapy and Pharmacology, 20 (3). pp. 203-206. ISSN 0344-5704