Lord, Rianne M., Mannion, James J., Hebden, Andrew J., Nako, Adi E., Crossley, Benjamin D., McMullon, Max W., Janeway, Felix D., Phillips, Roger M. and McGowan, Patrick C. (2014) Mechanistic and Cytotoxicity Studies of Group IV b-Diketonate Complexes. ChemMedChem Communications, 9 (6). pp. 1136-1139. ISSN 1860-7179

Group IV metal complexes have previously shown promise as novel anticancer agents. Here, we discuss the mechanistic and cytotoxic nature of a series of group IV b-diketonate coordina- tion complexes. Clear evidence that the ligands are exchangea- ble on the metal centre and that the b-diketonate ligands can act as potential drug delivery vehicles of the group IV metal ions was obtained. When evaluated for the cytotoxicity against human colon adenocarcinoma (HT-29) and human breast ade- nocarcinoma (MCF-7) cell lines, a general trend of decreasing potency down the group IV metals was observed. The most promising results obtained were for the hafnium complexes, with the tris diphenyl b-diketonate hafnium complex exhibit- ing IC50 values of 4.9