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Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins

Davies, Karen J. and Page, Michael I. (1990) Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins. Chemical Communications (20). pp. 1448-1450. ISSN 1359-7345
Abstract

The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T–) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T–.

Information
URI:
https://eprints.hud.ac.uk/id/eprint/6118
URI:
https://eprints.hud.ac.uk/id/eprint/6118
URI:
https://eprints.hud.ac.uk/id/eprint/6118
URI:
https://eprints.hud.ac.uk/id/eprint/6118
URI:
https://eprints.hud.ac.uk/id/eprint/6118
URI:
https://eprints.hud.ac.uk/id/eprint/6118
Title:
Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins
Creators:
Davies, Karen J. and Page, Michael I.
Identification Number:
10.1039/C39900001448
Official URL:
http://dx.doi.org/10.1039/C39900001448
Date:
October 1990
Subjects:
Q Science > Q Science (General)
Q Science > QD Chemistry
Schools:
School of Applied Sciences
Library
Item Type:
Article
Depositing User:
Sharon Beastall
Date Deposited:
06 Nov 2009 10:06
Revision:
11
Last Modified:
28 Aug 2021 10:52
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