Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins

Davies, Karen J.; Page, Michael I.

Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins

Davies, Karen J. and Page, Michael I. (1990) Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins. Chemical Communications (20). pp. 1448-1450. ISSN 1359-7345

Abstract
Information
Library
Statistics

[+][-]

Abstract

The rate of reaction of cephalosporins with alkoxide ions shows general acid-catalysed inhibition, which is attributed to the trapping of the anionic tetrahedral intermediate (T–) by proton donors to give the thermodynamically more stable neutral intermediate To at a rate which is faster than breakdown of T–.

Information

URI:

https://eprints.hud.ac.uk/id/eprint/6118

Title:

Reaction rates and thermodynamic equilibration of tetrahedral intermediates: the alcoholysis of cephalosporins

Creators:

Davies, Karen J. and Page, Michael I.

Identification Number:

10.1039/C39900001448

Official URL:

http://dx.doi.org/10.1039/C39900001448

Date: