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A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1998) A facile and highly stereoselective approach to a polycyclic isoindolinone ring system via an N-acyliminium ion cyclization reaction. Tetrahedron Letters, 39 (27). pp. 4905-4908. ISSN 0040-4039
Abstract

A highly diastereoselective synthesis of chiral ring-fused isoindolinone products, the skeleton of which is common to many naturally occurring and biologically active compounds, is achieved in only two synthetic steps from readily available precursors via an N-acyliminium ion cyclization reaction of an isoindolinone substrate.

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Item Type:
Article
Depositing User:
Sharon Beastall
Date Deposited:
05 Nov 2009 10:42
Revision:
12
Last Modified:
28 Aug 2021 10:52
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