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Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams

Page, Michael I., Hinchliffe, Paul S., Wood, J. Matthew, Harding, Lindsay P. and Laws, Andrew P. (2003) Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams. Bioorganic & Medicinal Chemistry Letters, 13 (24). pp. 4489-4492. ISSN 0960-894X
Abstract

β-Sultams are the sulfonyl analogues of β-lactams and N-acyl β-sultams are novel inactivators of the class C β-lactamase of Enterobacter cloacae P99. The rates of inactivation show a similar pH-rate dependence as that exhibited by the β-lactam antibiotics and with ESIMS data it is suggested that β-sultams sulfonylate the active site serine residue to form a sulfonate ester.

Information
URI:
https://eprints.hud.ac.uk/id/eprint/519
Title:
Novel mechanism of inhibiting b-lactamases by sulfonylation using b-sultams
Creators:
Page, Michael I., Hinchliffe, Paul S., Wood, J. Matthew, Harding, Lindsay P. and Laws, Andrew P.
Identification Number:
10.1016/j.bmcl.2003.08.082
Official URL:
http://dx.doi.org/10.1016/j.bmcl.2003.08.082
Date:
15 December 2003
Subjects:
Q Science > Q Science (General)
Q Science > QD Chemistry
Schools:
School of Applied Sciences
School of Applied Sciences > Biomolecular Sciences Research Centre
Library
Item Type:
Article
Depositing User:
Sara Taylor
Date Deposited:
08 Feb 2008 16:28
Revision:
22
Last Modified:
28 Aug 2021 10:38
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