Design and development of holders and a novel diffusion cell for advanced UV imaging to characterise pharmaceutical formulations

UV imaging has seen a rapid expansion in providing early insights into drug API behaviour in vivo due to the versatility of the UV imaging setups. These insights into API behaviour have proved useful in providing an understanding for phenomenon usually difficult to otherwise explain. The SDi2 UV imager offers a platform which facilitates UV imaging of drug compact intrinsic dissolution rate (IDR) determination as well as whole dose dissolution imaging.

The work presented in this thesis is a collaborative approach between the School of Applied Sciences and School of Engineering at the University of Huddersfield to expand the application of the SDi2 imaging instrument to characterise topical dosage forms (creams, gels, ointments etc.).