Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

Venkatesh, V., Wedge, Christopher J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, Peter J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Trans., 45 (33). pp. 13034-13037. ISSN 1477-9226

Abstract

We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.

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https://eprints.hud.ac.uk/id/eprint/30046

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https://eprints.hud.ac.uk/id/eprint/30046

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https://eprints.hud.ac.uk/id/eprint/30046

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https://eprints.hud.ac.uk/id/eprint/30046

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https://eprints.hud.ac.uk/id/eprint/30046

Title:

Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

Creators:

Venkatesh, V., Wedge, Christopher J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, Peter J.

Identification Number:

10.1039/C6DT01382A

Official URL:

http://dx.doi.org/10.1039/C6DT01382A

Date:

18 May 2016

Subjects:

Q Science > QD Chemistry

Schools:

School of Applied Sciences

Uncontrolled Keywords:

Electron paramagnetic resonance platinum complex spin trapping anticancer photoactivation

Library

Item Type:

Article

Depositing User:

Christopher Wedge

Date Deposited:

28 Nov 2016 11:09

Revision:

18

Last Modified:

28 Aug 2021 16:36

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