Nguyen, Nam-Trung, Ting, Teck-Hui, Yap, Yit-Fatt, Wong, Teck-Neng, Chai, John, Ong, Wee-Liat, Zhou, Junlong, Tan, Say-Hwa and Yobas, Levent (2007) Thermally mediated droplet formation in microchannels. Applied Physics Letters, 91 (8). 084102. ISSN 0003-6951

Precise dispensing of microdroplets is an important process for droplet-based microfluidics. The dropletformation by shear force between two immiscible fluids depends on their flow rates, the viscosities, and the interfacial tension. In this letter, the authors report the use of integrated microheater and temperature sensor for controlling the dropletformation process. The technique exploits the dependency on temperature of viscosities and interfacial tension. Using a relatively low heating temperature ranging from 25to70°C, the droplet diameter can be adjusted to over two times of its original value. The relatively low temperature range makes sure that this concept is applicable for droplets containing biological samples.