Forced convection heat transfer in a channel with different configurations of graphite foams is experimentally and numerically studied in this paper. The physical properties of graphite foams such as the porosity, pore diameter, density, permeability and Forchheimer coefficient are determined experimentally. The local temperatures at the surface of the heat source and the pressure drops across different configurations of graphite foams are measured. In the numerical simulations, the Navier–Stokes and Brinkman–Forchheimer equations are used to model the fluid flow in the open and porous regions, respectively. The local thermal non-equilibrium model is adopted in the energy equations to evaluate the solid and fluid temperatures. Comparisons are made between the experimental and simulation results. The results showed that the solid block foam has the best heat transfer performance at the expense of high pressure drop. However, the proposed configurations can achieve relatively good enhancement of heat transfer at moderate pressure drop.