Fluid flow and heat transfer characteristics in a channel with staggered porous blocks were numerically studied in this paper. The Navier–Stokes and Brinkman–Forchheimer equations were used to model the fluid flow in the open and porous regions, respectively. Coupling of the pressure and velocity fields was resolved using the SIMPLER algorithm. The local thermal equilibrium model was adopted in the energy equation to evaluate the solid and fluid temperatures. The effect of Darcy number, Reynolds number, porous block height and width on the velocity field were studied. In addition, the effects of the above parameters as well as the thermal conductivity ratio between the porous blocks and the fluid on the local heat transfer were analyzed. The pressure drops across the channel for different cases were discussed. The results show that the flow behavior and its associated local heat transfer are sensitive to the variation of the above parameters. It is predicted by the present study that an increase in the thermal conductivity ratio between the porous blocks and the fluid results in significant enhancement of heat transfer at the locations of the porous blocks.