Construction of Î²-Haloenamides via Direct Copper-Promoted Coupling of Lactams with 2-Chloro and 2-Bromo Vinyliodides.

Sun, Cuixiang, Camp, Jason and Weinreb, Steven M. (2006) Construction of Î²-Haloenamides via Direct Copper-Promoted Coupling of Lactams with 2-Chloro and 2-Bromo Vinyliodides. Organic Letters, 8 (9). pp. 1779-1781. ISSN 1523-7060

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Abstract

Cu(I)-catalyzed coupling of lactams with (E)-2-chlorovinyl iodides or (E)-2-bromovinyl iodides produces the corresponding Î²-halo enamides in moderate to excellent yields. E.g., in the presence of CuI and MeNHCH2CH2NHMe, coupling of (E)-2-chlorovinyl iodide I with lactam II gave 43% Î²-halo enamide III. [on SciFinder(R)]

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URI:

https://eprints.hud.ac.uk/id/eprint/22279

Title:

Construction of Î²-Haloenamides via Direct Copper-Promoted Coupling of Lactams with 2-Chloro and 2-Bromo Vinyliodides.

Creators:

Sun, Cuixiang, Camp, Jason and Weinreb, Steven M.

Identification Number:

10.1021/ol060093a

Official URL:

http://dx.doi.org/10.1021/ol060093a

Date:

March 2006

Subjects:

Q Science > Q Science (General)
Q Science > QD Chemistry

Schools:

School of Applied Sciences

Additional Information:

Unmapped bibliographic data: PY - 2006/// [EPrints field already has value set] M3 - 10.1021/ol060093a [Field not mapped to EPrints] JA - Org. Lett. [Field not mapped to EPrints]

Uncontrolled Keywords:

halo enamide prepn, copper catalyst coupling lactam chlorovinyl bromovinyl iodide

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Item Type:

Article

Depositing User:

Sara Taylor

Date Deposited:

13 Nov 2014 16:59

Revision:

Last Modified:

28 Aug 2021 11:43