There are many traditional methods to find the optimum parameters of a tuned mass damper (TMD) subject to stationary base excitations. It is very difficult to obtain the optimum parameters of a TMD subject to non-stationary base excitations using these traditional optimization techniques. In this paper, by applying particle swarm optimization (PSO) algorithm as a novel evolutionary algorithm, the optimum parameters including the optimum mass ratio, damper damping and tuning frequency of the TMD system attached to a viscously damped single-degree-of-freedom main system subject to non-stationary excitation can be obtained when taking either the displacement or the acceleration mean square response, as well as their combination, as the cost function. For simplicity of presentation, the non-stationary excitation is modeled by an evolutionary stationary process in the paper. By means of three numerical examples for different types of non-stationary ground acceleration models, the results indicate that PSO can be used to find the optimum mass ratio, damper damping and tuning frequency of the non-stationary TMD system, and it is quite easy to be programmed for practical engineering applications