Venkatesh, V., Wedge, Christopher J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, Peter J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Trans., 45 (33). pp. 13034-13037. ISSN 1477-9226
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Abstract
We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.
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Uncontrolled Keywords: | Electron paramagnetic resonance platinum complex spin trapping anticancer photoactivation |
Subjects: | Q Science > QD Chemistry |
Schools: | School of Applied Sciences |
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Depositing User: | Christopher Wedge |
Date Deposited: | 28 Nov 2016 11:09 |
Last Modified: | 28 Aug 2021 16:36 |
URI: | http://eprints.hud.ac.uk/id/eprint/30046 |
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