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Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex

Venkatesh, V., Wedge, Christopher J., Romero-Canelón, Isolda, Habtemariam, Abraha and Sadler, Peter J. (2016) Spin-labelled photo-cytotoxic diazido platinum(iv) anticancer complex. Dalton Trans., 45 (33). pp. 13034-13037. ISSN 1477-9226

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Abstract

We report the synthesis and characterisation of the nitroxide spin-labelled photoactivatable Pt(IV) prodrug trans,trans,trans-[Pt(N3)2(OH)(OCOCH2CH2CONH-TEMPO)(Py)2] (Pt-TEMPO, where TEMPO = 2,2,6,6-tetramethylpiperidine 1-oxyl). Irradiation with blue visible light gave rise to Pt(II) and azidyl as well as nitroxyl radicals. Pt-TEMPO exhibited low toxicity in the dark, but on photoactivation was as active towards human ovarian cancer cells as the clinical photosensitizer chlorpromazine and much more active than the anticancer drug cisplatin under the conditions used.

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Item Type: Article
Uncontrolled Keywords: Electron paramagnetic resonance platinum complex spin trapping anticancer photoactivation
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Christopher Wedge
Date Deposited: 28 Nov 2016 11:09
Last Modified: 01 Dec 2016 07:21
URI: http://eprints.hud.ac.uk/id/eprint/30046

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