Sun, Cuixiang, Camp, Jason and Weinreb, Steven M. (2006) Construction of β-Haloenamides via Direct Copper-Promoted Coupling of Lactams with 2-Chloro and 2-Bromo Vinyliodides. Organic Letters, 8 (9). pp. 1779-1781. ISSN 1523-7060

Cu(I)-catalyzed coupling of lactams with (E)-2-chlorovinyl iodides or (E)-2-bromovinyl iodides produces the corresponding β-halo enamides in moderate to excellent yields. E.g., in the presence of CuI and MeNHCH2CH2NHMe, coupling of (E)-2-chlorovinyl iodide I with lactam II gave 43% β-halo enamide III. [on SciFinder(R)]

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