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Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol

Karki, Shyam, Frisic, Tomislav, Fabian, Lazlo, Laity, Peter R., Day, Graeme M. and Jones, William (2009) Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol. Advanced Materials, 21 (38-39). pp. 3905-3909. ISSN 0935-9648
Abstract

Poor mechanical properties of paracetamol are improved through the strategy of cocrystal formation. Mechanochemical screening by liquid-assisted grinding generated four cocrystals of paracetamol that readily form tablets by direct compression. Computational studies reveal the mechanical properties can be related to structural features, before all the formation of hydrogen-bonded layers.

Information
URI:
https://eprints.hud.ac.uk/id/eprint/8791
URI:
https://eprints.hud.ac.uk/id/eprint/8791
Title:
Improving Mechanical Properties of Crystalline Solids by Cocrystal Formation: New Compressible Forms of Paracetamol
Creators:
Karki, Shyam, Frisic, Tomislav, Fabian, Lazlo, Laity, Peter R., Day, Graeme M. and Jones, William
Identification Number:
10.1002/adma.200900533
Official URL:
http://dx.doi.org/10.1002/adma.200900533
Date:
October 2009
Subjects:
Q Science > Q Science (General)
Schools:
School of Applied Sciences
Library
Item Type:
Article
Depositing User:
Peter Laity
Date Deposited:
11 Oct 2010 11:24
Revision:
10
Last Modified:
28 Aug 2021 11:00
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