Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines

Hemming, Karl (2010) Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines. Tetrahedron Letters, 51 (37). pp. 4859-4861. ISSN 0040-4039

Abstract

Intramolecular 1,3-dipolar cycloaddition between an alkyne and an azide leads to a series of 1,2,3-triazolo-fused 1,4-benzodiazepines, 1,2,5-benzothiadiazepines, pyrrolobenzodiazepines and pyrrolobenzothiadiazepines (8 examples). The products are privileged structures in medicinal chemistry. The precursor azido alkynes are obtained, usually as transient intermediates, by treatment of the corresponding aldehydes (derived from α-amino acids) with the Bestmann-Ohira reagent.

Information

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

URI:

https://eprints.hud.ac.uk/id/eprint/8382

Title:

Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines

Creators:

Hemming, Karl

Identification Number:

10.1016/j.tetlet.2010.07.050

Official URL:

http://dx.doi.org/10.1016/j.tetlet.2010.07.050

Date:

August 2010

Subjects:

Q Science > QD Chemistry

Schools:

School of Applied Sciences

Library

Item Type:

Article

Depositing User:

Date Deposited:

25 Aug 2010 14:39

Revision:

15

Last Modified:

28 Aug 2021 22:06

Documents

[thumbnail of TETL38088.pdf]

TETL38088.pdf - Published Version
Restricted to Repository staff only

Download (485kB)

Statistics

CORE (COnnecting REpositories)

CORE (COnnecting REpositories)

Tools

Add to Any

Add to Email