Gensmantel, Nigel P. and Page, Michael I. (1978) A tetrahedral intermediate in the aminolysis of benzylpenicillin. Chemical Communications (9). pp. 374-375. ISSN 1359-7345
Abstract

There is a non-linear dependent of the rate of aminolysis of benzylpenicillin upon hydroxide ion concentration which is interpreted in terms of formation of a tetrahedral intermediate; the rate of breakdown of the intermediate into reactants is ca. 109 s–1

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