Beard, Timothy M. and Page, Michael I. (1998) Enantioselective biotransformations using rhodococci. Antonie van Leeuwenhoek, 74 (1/3). pp. 99-106. ISSN 0003-6072
Abstract

The use of enzymes and whole cells in enantioselective biotransformation reactions is briefly reviewed. A Rhodococcus strain is shown to possess nitrile hydratase and amidase activity. The organism can be used for the enantioselective biotransformation of racemic -amino amides to (S) -amino acids with an enantiomeric excess (ee) of > 98%. Enantioselectivity is effectively time independent allowing easy quantitative conversion of racemic mixtures into enantiomerically pure -amino amides and -amino acids. The reaction is effective for a wide range of - substituents. The pH-dependence of the reaction indicates that the -amino amide is bound to the amidase enzyme in its neutral unprotonated form.

Information
Library
Statistics

View Item (login required)
View Item (login required)
Add to AnyAdd to TwitterAdd to FacebookAdd to LinkedinAdd to PinterestAdd to Email