Clayden, Jonathan, Moran, Wesley J., Edwards, Paul J. and LaPlante, Steven R. (2009) The Challenge of Atropisomerism in Drug Discovery. Angewandte Chemie International Edition, 48 (35). pp. 6398-6401. ISSN 14337851
Abstract

A twist in the tale: Recent reports have highlighted solutions to the problems encountered when drug candidates exist as slowly interconverting conformers or atropisomers (see scheme). This Minireview brings together the various strategies that have been adopted and proposes a general approach to handling an aspect of stereochemistry which has received little attention from drug regulatory agencies.

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