Scott, Fraser J., Khalaf, Abedawn I., Giordani, Federica, Wong, Pui Ee, Duffy, Sandra, Barrett, Michael, Avery, Vicky M. and Suckling, Colin J. (2016) An evaluation of Minor Groove Binders as anti- Trypanosoma brucei brucei therapeutics. European Journal of Medicinal Chemistry, 116. pp. 116-125. ISSN 0223-5234
Abstract

A series of 32 structurally diverse MGBs, derived from the natural product distamycin, was evaluated for activity against Trypanosoma brucei brucei. Four compounds have been found to possess significant activity, in the nanomolar range, and represent hits for further optimisation towards novel treatments for Human and Animal African Trypanosomiases. Moreover, SAR indicates that the head group linking moiety is a significant modulator of biological activity

Library
Documents
[img]
Preview
An evaluation of Minor Groove Binders as anti-trypanosoma brucei brucei therapeutics_published.pdf - Published Version
Available under License Creative Commons Attribution.

Download (636kB) | Preview
Statistics

Downloads

Downloads per month over past year