Waters, Laura J., Shokry, Dina and Parkes, Gareth M.B (2016) Predicting human intestinal absorption in the presence of bile salt with micellar liquid chromatography. Biomedical Chromatography. ISSN 1099-0801

Understanding intestinal absorption for pharmaceutical compounds is vital to estimate bioavailability and therefore the in vivo potential of a drug. This study considers the application of micellar liquid chromatography (MLC) to predict passive intestinal absorption with a selection of model compounds. MLC is already known to aid prediction of absorption using simple surfactant systems however, with this study the focus was on the presence of a more complex, bile salt surfactant, as would be encountered in the in vivo environment. As a result, MLC using a specific bile salt has been confirmed as an ideal in vitro system to predict the intestinal permeability for a wide range of drugs, through the development of a quantitative partition-absorption relationship. MLC offers many benefits including environmental, economic, time-saving and ethical advantages compared with the traditional techniques employed to obtain passive intestinal absorption values.

Waters_et_al-2016-Biomedical_Chromatography.pdf - Accepted Version

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