Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase

Bounaga, Sakina, Galleni, Moreno, Laws, Andrew P. and Page, Michael I. (2001) Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase. Bioorganic & Medicinal Chemistry Letters, 9 (2). pp. 503-507. ISSN 0960-894X

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Abstract

Several cysteinyl peptides have been synthesised and shown to be reversible competitive inhibitors of the Bacillus cereus metallo-β-lactamase. The pH dependence of pKi indicates that the thiol anion displaces hydroxide ion from the active site zinc(II). , -Peptides bind to the enzyme better than other diastereoisomers, which is compatible with the predicted stereochemistry of the active site

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Title:

Cysteinyl peptide Inhibitors of Bacillus cereus Zinc β-Lactamase

Creators:

Bounaga, Sakina, Galleni, Moreno, Laws, Andrew P. and Page, Michael I.

Identification Number:

10.1016/S0968-0896(00)00257-1

Official URL:

http://dx.doi.org/10.1016/S0968-0896(00)00257-1

Date:

2001

Subjects:

Q Science > Q Science (General)
Q Science > QD Chemistry

Schools:

School of Applied Sciences
School of Applied Sciences > Biomolecular Sciences Research Centre

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Article

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Date Deposited:

17 Oct 2008 11:13

Revision:

13

Last Modified:

28 Aug 2021 10:42

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