Ngwerume, Simbarashe and Camp, Jason (2010) Synthesis of Highly Substituted Pyrroles via Nucleophilic Catalysis. Journal of Organic Chemistry, 75 (18). pp. 6271-6274. ISSN 0022-3263
Abstract

A nucleophilic catalysis method providing a concise synthesis of di-, tri-, and tetrasubstituted pyrroles is described. This regioselective one-pot method relies on nucleophilic catalysis of the intermol. addn. of oximes to activated alkynes and thermal rearrangement of the in situ generated O-vinyl oximes to form pyrroles that contain a functional group handle at the C3/C4 position. [on SciFinder(R)]

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