Bishop, Emily, Yusuf, Alex, Stephenson, John and Airley, Rachel (2013) A metabolic phenotype in sarcoma? Repression of skeletal muscle transcription factor mondo A (Mlx- Interacting Protein). In: 2nd International Conference on Tumor Microenvironment and Cellular Stress: Signaling, Metabolism, Imaging and Therapeutic Targets, September 27-October 2, 2013, Corfu, Greece. (Unpublished)

MondoA (MLX-interacting protein) is a bHLH transcription
factor primarily located in skeletal muscle which drives
glucose-dependent pathways such as glycolysis and the
expression of TXNIP (thioredoxin-interacting protein). A
Mondo-A/TXNIP feedback pathway has been defined
previously which is believed to regulate the uptake of
glucose by tumours in response to increased glycolysis and
production of lactate1. The aim of this study was to profile
MondoA protein expression in muscle-derived sarcomas and
to determine how MondoA may interact with pathways
associated with the Warburg Effect, lipid metabolism and
pathways associated with sarcoma.


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