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The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O

Dillon, Michael P., Hayes, Martin A., Simpson, Thomas J. and Sweeney, Joseph B. (1991) The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O. Bioorganic & Medicinal Chemistry Letters, 1 (4). pp. 223-226. ISSN 0960-894X
Abstract

Bakers' yeast reduction of ethyl acetoacetate and ethyl 3-oxo-hexanoate in D2O gives the corresponding /gb-hydroxy esters bearing an iosotopic label at the activated methlene position, in good yield and high enantiomeric excess. These compounds have been converted to their N-acetylcysteamine thioesters for use in biosynthetic studies.

Information
URI:
https://eprints.hud.ac.uk/id/eprint/15420
Title:
The synthesis of isotopically labelled N-acetylcysteamine thioesters utilising a baker's yeast reduction in D2O
Creators:
Dillon, Michael P., Hayes, Martin A., Simpson, Thomas J. and Sweeney, Joseph B.
Identification Number:
10.1016/S0960-894X(00)80257-7
Official URL:
http://dx.doi.org/10.1016/S0960-894X(00)80257-7
Date:
April 1991
Subjects:
Q Science > QD Chemistry
Schools:
School of Applied Sciences
Library
Item Type:
Article
Depositing User:
Joseph Sweeney
Date Deposited:
09 Oct 2012 09:28
Revision:
10
Last Modified:
28 Aug 2021 11:22
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