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Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam

Cantrill, Alex A., Hall, Lee D., Jarvis, Ashley N., Osborn, Helen M. I., Raphy, Jenny and Sweeney, Joseph B. (1996) Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam. Chemical Communications (23). p. 2631. ISSN 1359-7345
Abstract

The aza-Darzens reaction of the chiral enolate derived from bromoacetylcamphorsultam 1 with N-(diphenyl-phosphinyl)aryl- and tert-butyl-methanimines proceeds in good yield to give cis-N-(diphenylphosphinyl)aziridinylcarbonyl sultams with high de. Monochiral cis-aziridinecarboxylates may be obtained in acceptable yield by hydrolysis of these sultams.

Information
URI:
https://eprints.hud.ac.uk/id/eprint/15395
URI:
https://eprints.hud.ac.uk/id/eprint/15395
URI:
https://eprints.hud.ac.uk/id/eprint/15395
URI:
https://eprints.hud.ac.uk/id/eprint/15395
Title:
Asymmetric aziridine synthesis via aza-Darzens reaction of bromoacylcamphorsultam
Creators:
Cantrill, Alex A., Hall, Lee D., Jarvis, Ashley N., Osborn, Helen M. I., Raphy, Jenny and Sweeney, Joseph B.
Identification Number:
10.1039/cc9960002631
Official URL:
http://dx.doi.org/10.1039/cc9960002631
Date:
January 1996
Subjects:
Q Science > QD Chemistry
Schools:
School of Applied Sciences
Library
Item Type:
Article
Depositing User:
Joseph Sweeney
Date Deposited:
17 Oct 2012 13:01
Revision:
10
Last Modified:
28 Aug 2021 11:22
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