Roberts, Edward, Sançon, Julien P., Sweeney, Joseph B. and Workman, James A. (2003) First Efficient and General Copper-Catalyzed [2,3]-Rearrangement of Tetrahydropyridinium Ylids. Organic Letters, 5 (25). pp. 4775-4777. ISSN 1523-7060
Abstract

The factors affecting the copper-catalyzed rearrangement of ammonium ylids derived from tetrahydropyridines and diazoesters have been examined,and the first examples of high-yielding metal-catalyzed [2,3]-sigmatropic rearrangements of a wide range of such ylids are reported. The nature of the α-substituent in the diazo component of the reaction has a dramatic effect upon the yields of the reaction, with electron-withdrawing substituents enhancing the yield of the reaction.

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