Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion

Abdelrahim, Mohamed E., Assi, Khaled H. and Chrystyn, Henry (2011) Relative bioavailability of terbutaline to the lung following inhalation, using urinary excretion. British Journal of Clinical Pharmacology, 71 (4). pp. 608-610. ISSN 1365-2125

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Abstract

The urinary salbutamol pharmacokinetic to determine relative lung and systemic bioavailability has been extended to terbutaline.

Mean(SD) urinary terbutaline 0.5h post inhalation, in 12 volunteers, with (IC) and without (I) oral charcoal and oral (O) dosing was 7.4(2.2), 6.5(2.1) and 0.2(0.2)µg. I and IC were similar and both significantly greater than O (p < 0.001). Urinary 24h terbutaline post I was similar to IC + O. The method was linear and reproducible similar to that of the urinary salbutamol method.

The urinary salbutamol pharmacokinetic method post inhalation applies to terbutaline. Terbutaline study doses can replace routine salbutamol during these studies when patients are studied.

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Sara Taylor
Date Deposited:	17 Mar 2011 10:58
Last Modified:	17 Mar 2011 14:35
URI:	http://eprints.hud.ac.uk/id/eprint/9855

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