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Olajide, Olumayokun A, Ogunleye, Babatunde R. and Erinle, Temitope O. (2004) Anti-inflammatory properties of Amaranthus Spinosus Leaf Extract. Pharmaceutical Biology, 42 (7). pp. 521-525. ISSN 1388-0209
Metadata only available from this repository.Abstract
The methanol extract of Amaranthus spinosus L. leaves was evaluated for anti-inflammatory activities in different animal models. The effect of the plant extract was also studied on castor oil–induced diarrhea and gastric mucosal integrity. The extract (25–100 mg/kg) inhibited the carrageenan-induced rat paw edema and produced significant (p < 0.05) inhibition of acetic acid–induced increased vascular permeability. Inhibition of the cotton pellet granuloma was also inhibited by 100 mg/kg of the plant extract. Analgesic activity was exhibited with the significant and dose-related reduction in the number of writhings induced with acetic acid, as well reduction in paw licking induced by injection of formalin in mice. The extract (50 and 100 mg/kg) produced gastric erosion in rats, following repeated administration for 4 days, and with 25–100 mg/kg of the extract, there was a statistically significant (p < 0.05) reduction in castor oil–induced diarrhea in rats. These results demonstrate the anti-inflammatory properties of the leaf extract of A. spinosus. It is also suggested that the plant extract probably acts by the inhibition of prostaglandin biosynthesis.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Schools: | School of Applied Sciences |
| Related URLs: | |
| Depositing User: | Olumayokun Olajide |
| Date Deposited: | 10 Nov 2010 10:15 |
| Last Modified: | 10 Nov 2010 10:15 |
| URI: | http://eprints.hud.ac.uk/id/eprint/8991 |
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