Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark.

Olajide, Olumayokun A, Awe, S O, Makinde, J M, Ekhelar, A I, Olusola, A, Morebise, Olugbenga and Okpako, D T (2000) Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark. Journal of ethnopharmacology, 71 (1-2). pp. 179-186. ISSN 0378-8741

Metadata only available from this repository.

Abstract

The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Schools:	School of Applied Sciences
Related URLs:	Author
Depositing User:	Olumayokun Olajide
Date Deposited:	10 Nov 2010 11:37
Last Modified:	10 Nov 2010 11:37
URI:	http://eprints.hud.ac.uk/id/eprint/8986

Downloads

Repository Staff Only: item control page

View Item