Olajide, Olumayokun A, Okpako, David T and Makinde, J M (2003) Anti-inflammatory properties of Bridelia ferruginea stem bark. Inhibition of lipopolysaccaride-induced septic shock and vascular permeability. Journal of ethnopharmacology, 88 (2-3). pp. 221-224. ISSN 0378-8741
Metadata only available from this repository.Abstract
The anti-inflammatory activity of the aqueous extract of Bridelia ferruginea stem bark was further evaluated in models which are mediated by tumour necrosis factor-alpha (TNFalpha). The effect of the extract on lipopolysaccharide (LPS)-induced septic shock was evaluated by measuring the number of deaths and the levels of serum alanine and aspartate aminotransferases following intraperitoneal injection of LPS (1 microg/kg) into D-galactosamine-primed mice. LPS-induced vascular permeability on the back skin of mice was measured by the local accumulation of Evan's blue after subcutaneous injection of LPS. Pre-treatment with Bridelia ferruginea extract (10-80 mg/kg) produced a dose-dependent inhibition of the septic shock syndrome in mice, with 80 mg/kg of the extract exhibiting comparable activity as pentoxifylline (100 mg/kg). LPS-induced dye leakage in the skin of mice was also suppressed by the extract (10-80 mg/kg). Our study suggests that one of the mechanisms of the anti-inflammatory effects of Bridelia ferruginea possibly involve the suppression of TNFalpha up-regulation.
Item Type: | Article |
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Subjects: | R Medicine > RM Therapeutics. Pharmacology |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Olumayokun Olajide |
Date Deposited: | 10 Nov 2010 11:16 |
Last Modified: | 28 Aug 2021 11:01 |
URI: | http://eprints.hud.ac.uk/id/eprint/8982 |
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