Griffin, K. F., Conway, Barbara R, Alpar, H.O. and Williamson, E.D. (1998) Immune responses to V antigen of Yersinia pestis co-encapsulated with IFN-y;: effect of dose and formulation. Vaccine, 16 (5). pp. 517-521. ISSN 0264-410X
Metadata only available from this repository.Abstract
Induction of systemic immune responses after intraperitoneal inoculation of poly(L)lactide microspheres containing the V antigen of Yersinia pestis co-encapsulated with IFN-γ were investigated. Serum antibody responses and T cell proliferative responses were measured in groups of Balb/c mice which were injected intraperitoneally with single or double emulsion preparations of either V/IFN-γ or V alone in a range of dose levels. Groups which received V antigen co-encapsulated with IFN-γ produced higher V-specific antibody responses, predominantly of the IgG1 isotype. Administration of 25 μg V/IFN-γ in a single emulsion resulted in a significantly increased (p<0.05) splenic T cell proliferative response to V antigen compared with other formulations. It was concluded that IFN-γ co-encapsulated with V antigen in poly(L)lactide microspheres acted as an adjuvant and increased antigen specific systemic immune responses. Therefore, co-encapsulation with IFN-γ may result in effective single dose vaccines by increasing the immunogenicity of the formulations.
Item Type: | Article |
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Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
Schools: | School of Applied Sciences School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention |
Related URLs: | |
Depositing User: | Sharon Beastall |
Date Deposited: | 05 Nov 2010 09:49 |
Last Modified: | 28 Aug 2021 11:01 |
URI: | http://eprints.hud.ac.uk/id/eprint/8958 |
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