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Skin delivery potency and antitumor activities of temozolomide ester prodrugs

Suppasansatorn, Panassaya, Wang, G, Conway, Barbara R, Wang, W and Wang, Y (2006) Skin delivery potency and antitumor activities of temozolomide ester prodrugs. Cancer Letters, 244 (1). pp. 42-52. ISSN 0304-3835

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Clinical trials have shown temozolomide to be an effective agent for treatment of malignant melanoma. In order to investigate its suitability for delivery via the skin, a series of temozolomide esters was synthesized as prodrugs. In vitro assays demonstrated temozolomide, temozolomide acid and the hexyl ester equi-effective against selected cancer cell lines. The susceptibility of the esters to enzyme hydrolysis and their effectiveness for application to the skin were investigated. The esters effectively diffuse through rat skin and the hexyl ester demonstrated profound potency for penetrating through skin. Topical application of 5% (w/v) hexyl ester in DMSO solution on a mouse model demonstrated a significant inhibition of tumor growth. These results suggest that temozolomide esters could be an effective alternative to temozolomide in the treatment of skin cancer.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
School of Human and Health Sciences > Institute for Skin Integrity and Infection Prevention
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Depositing User: Sharon Beastall
Date Deposited: 04 Nov 2010 12:27
Last Modified: 28 Aug 2021 11:01


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