Hemming, Karl (2010) Intramolecular 1,3-dipolar cycloaddition as a route to triazolobenzodiazepines and pyrrolobenzodiazepines. Tetrahedron Letters, 51 (37). pp. 4859-4861. ISSN 0040-4039
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Abstract
Intramolecular 1,3-dipolar cycloaddition between an alkyne and an azide leads to a series of 1,2,3-triazolo-fused 1,4-benzodiazepines, 1,2,5-benzothiadiazepines, pyrrolobenzodiazepines and pyrrolobenzothiadiazepines (8 examples). The products are privileged structures in medicinal chemistry. The precursor azido alkynes are obtained, usually as transient intermediates, by treatment of the corresponding aldehydes (derived from α-amino acids) with the Bestmann-Ohira reagent.
Item Type: | Article |
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Subjects: | Q Science > QD Chemistry |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Karl Hemming |
Date Deposited: | 25 Aug 2010 14:39 |
Last Modified: | 28 Aug 2021 22:06 |
URI: | http://eprints.hud.ac.uk/id/eprint/8382 |
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