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Controlling the Release of Proteins/Peptides via the Pulmonary Route

Shoyele, Sunday (2008) Controlling the Release of Proteins/Peptides via the Pulmonary Route. In: Drug Delivery Systems. Methods in Molecular Biology, 437 . Humana Press, New York, USA, pp. 141-148. ISBN 978-1-59745-210-6

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The inhalation route is seen as the most promising non-invasive alternative for the delivery of proteins; however, the short duration of activity of drugs delivered via this route brought about by the activities of alveolar macrophages and mucociliary clearance means there is a need to develop controlled release system to prolong the activities of proteins delivered to the lung. Polymeric materials such as (d,l)-poly(lactic glycolic acid) (PLGA), chitosan and poly(ethylene glycol) (PEGs) have been used for controlled release of proteins. Other systems such as liposomes and microcrystallization have also proved effective.
This chapter gives a more detailed understanding of these techniques and the manufacture of the delivery systems.

Item Type: Book Chapter
Subjects: R Medicine > R Medicine (General)
Q Science > QD Chemistry
R Medicine > RC Internal medicine
Schools: School of Applied Sciences
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Depositing User: Sara Taylor
Date Deposited: 26 Jan 2010 10:24
Last Modified: 28 Aug 2021 10:54


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