Patel, Nilesh, Chambers, Christopher Steven and Hemming, Karl (2009) The synthesis of benzothiadiazines, benzothiadiazepines and benzothiadiazocines from intramolecular azide reactions and iodocyclisations. Synlett, 2009 (18). pp. 3043-3047. ISSN 09365214
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Abstract
N-Homoallyl-substituted (2-aminoaryl)sulfonamides undergo intramolecular iodocyclisation to furnish aziridine-fused 1,2,6-benzothiadiazocines. The identical aziridine-fused 1,2,6-benzothiadiazocines were also available from an intramolecular azide to alkene 1,3-diploar cycloaddition involving the corresponding N-homoallylic (2-azidoaryl)sulfonamides in boiling carbon tetrachloride. The use of boiling DMF as solvent for the same reaction gave pyrrolo-fused benzothiadiazines. Intramolecular azide-alkene cycloadditions also allowed access to aziridine-fused pyrrolobenzothiadiazepines and pyrrolobenzodiazepines
Item Type: | Article |
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Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
Schools: | School of Applied Sciences |
Related URLs: | |
Depositing User: | Sara Taylor |
Date Deposited: | 12 Nov 2009 09:25 |
Last Modified: | 28 Aug 2021 22:36 |
URI: | http://eprints.hud.ac.uk/id/eprint/6198 |
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