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The esterase catalysed resolution of lactones and spirodilactone

Barton, Patrick and Page, Michael I. (1993) The esterase catalysed resolution of lactones and spirodilactone. Journal of the Chemical Society, Perkin Transactions 2 (12). pp. 2317-2318. ISSN 1472-779X

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The pig liver esterase catalysed hydrolysis of spirodilactone and -phenyl--butyrolactone gives optically active products (>90% e.e., after 50% reaction). However, the similarly substituted acyclic ester analogues of the lactone do not exhibit enantioselectivity suggesting that the acylation step shows the selectivity. Racemic spirodilactone can be converted, in principle, entirely into one of its enantiomers.

Item Type: Article
Subjects: Q Science > Q Science (General)
Q Science > QD Chemistry
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 06 Nov 2009 08:29
Last Modified: 28 Aug 2021 10:52


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