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A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives

Allin, Steven M., Northfield, Christopher J., Page, Michael I. and Slawin, Alexandra M.Z. (1999) A highly diastereoselective synthesis of 3-substituted isoindolin-1-one dericatives. Tetrahedron Letters, 40 (1). pp. 143-146. ISSN 0040-4039

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A highly diastereoselective method for the synthesis of 3-substituted isoindolin-1-ones has been developed through application of a tricyclic lactam substrate as an N-acyliminium ion precursor. Ring-opening of the tricyclic lactam with triethylsilane as hydride source generates the targets with up to exclusive levels of diastereoselectivity. This approach compliments that reported in the preceding paper.

Item Type: Article
Subjects: Q Science > Q Science (General)
Schools: School of Applied Sciences
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Depositing User: Sharon Beastall
Date Deposited: 04 Nov 2009 12:31
Last Modified: 28 Aug 2021 10:52


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