Computing and Library Services - delivering an inspiring information environment

Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer

Adams, Ralph W., Aguilar, Juan A., Atkinson, Kevin D., Cowley, Michael J., Elliott, Paul I., Duckett, Simon B., Green, Gary G. R., Khazal, Iman G., López-Serrano, Joaquín and Williamson, David C. (2009) Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer. Science, 323 (5922). pp. 1708-1711. ISSN 0036-8075

Metadata only available from this repository.


The sensitivity of both nuclear magnetic resonance spectroscopy and magnetic resonance imaging is very low because the detected signal strength depends on the small population difference between spin states even in high magnetic fields. Hyperpolarization methods can be used to increase this difference and thereby enhance signal strength. This has been achieved previously by incorporating the molecular spin singlet para-hydrogen into hydrogenation reaction products. We show here that a metal complex can facilitate the reversible interaction of para-hydrogen with a suitable organic substrate such that up to an 800-fold increase in proton, carbon, and nitrogen signal strengths are seen for the substrate without its hydrogenation. These polarized signals can be selectively detected when combined with methods that suppress background signals.

Item Type: Article
Subjects: Q Science > QD Chemistry
Schools: School of Applied Sciences
School of Applied Sciences > Materials and Catalysis Research Centre
Related URLs:
Depositing User: Graham Stone
Date Deposited: 29 Apr 2009 10:11
Last Modified: 28 Aug 2021 10:46


Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©