Extraction, Physicochemical Characterisation and Applications of Psyllium Seed Gum in Developing Anti-reflux Formulations

Yousaf, Maria (2019) Extraction, Physicochemical Characterisation and Applications of Psyllium Seed Gum in Developing Anti-reflux Formulations. Masters thesis, University of Huddersfield.

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Abstract

The anti-reflux formulations have brought a dynamic advancement in the treatment of uncomplicated GORD. This treatment approach applies the maintenance of the normal physiology of gastric conditions by the formation of a physical barrier on top of the gastric contents, which has the potential to prevent oesophageal complications. Regarding this, the use of bio-resourced raft-forming agents can aid in overcoming the barriers of affordability and limited availability concerns associated with alginates. Thus, the current research project was designed as a proof of concept to explore new sustainable biopolymers that can be used for the development of anti-reflux raft formulations. Psyllium seed was selected as a natural material, and a systematic approach was adopted to develop an extraction protocol to isolate and develop a biopolymer. Moreover, an attempt was made to develop a series of anti-reflux formulations, and their performance was tested against alginate, which served as a control. The results indicated that psyllium seed gum formulations have the potential to develop raft on its contact with gastric acid and its strength with carbopol (2 % w/w) combination was 5.77 ± 0.55. In conclusion, this study has provided a new material, which has raft-forming potential, which can be used to develop anti-reflux formulations for the management of GORD.

Item Type:	Thesis (Masters)
Subjects:	R Medicine > RS Pharmacy and materia medica
Schools:	School of Applied Sciences
Depositing User:	Andrew Strike
Date Deposited:	17 Feb 2020 15:51
Last Modified:	28 Aug 2021 14:40
URI:	http://eprints.hud.ac.uk/id/eprint/35184

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