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Structural and functional investigation of molybdoflavoenzymes in evolutionary diverse organisms

Kadi, Ibrahim (2019) Structural and functional investigation of molybdoflavoenzymes in evolutionary diverse organisms. Masters thesis, University of Huddersfield.

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Abstract

The molybdoflavoenzymes (MFEs), aldehyde oxidase (AOX) and xanthine oxidoreductase (XOR) catalyse the oxidation of many drugs, environmental pollutants and N-heterocyclic compounds. MFEs are enzymes that contain flavin adenine dinucleotide (FAD), iron sulphur domain [2Fe-2S] and molybdenum cofactor domain (Moco). This research study examined the structural evolution of MFEs in chordates and the effects of polymorphisms on vertebrate MFEs. Numerous databases such as NCBI were used multiple alongside alignment software such as CLC Sequence Viewer and UGENE.

Item Type: Thesis (Masters)
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Schools: School of Applied Sciences
Depositing User: Andrew Strike
Date Deposited: 19 Nov 2019 15:37
Last Modified: 19 Nov 2019 15:45
URI: http://eprints.hud.ac.uk/id/eprint/35091

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