Search:
Computing and Library Services - delivering an inspiring information environment

Formulation and evaluation of fluconazole loaded nanospongies for improved topical drug delivery

Abbas, Nasir, Hussain, Amjad, Ahsan Hafiz, Muhuammad and Perveen, Kausar (2017) Formulation and evaluation of fluconazole loaded nanospongies for improved topical drug delivery. British Journal of Pharmacy, 2 (2). pp. 41-42. ISSN 2058-8356

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (597kB) | Preview

Abstract

Fluconazole (an antifungal drug) loaded nanosponges (NS) were prepared by an emulsion solvent diffusion method using ethyl cellulose as the polymer. Prepared formulations were evaluated for various physicochemical parameters and in-vitro drug release. NS of fluconazole were discrete, free flowing nanosized particles with perforated orange peel-like morphology as shown by SEM analysis. A topical hydrogel formulation based on the drug loaded NS showed a prolonged release profile for the drug. Kinetic modelling on release data showed that the best fitted model was Higuchi model and release mechanism was by Fickian diffusion. FTIR and PXRD results confirmed the absence of any drug polymer interaction and stability of drug in the delivery system.

Item Type: Article
Uncontrolled Keywords: nanosponges, fluconazole, sustain relese, topical drug delivery
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 17 Jul 2018 12:00
Last Modified: 16 Oct 2018 20:45
URI: http://eprints.hud.ac.uk/id/eprint/34620

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©