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Synthesis and evaluation of novel antifungal agents targeted to the plasma membrane H[+]-ATPase

Patel, Dhruvnesh V, Bassin, J Paul and Griffiths, David G (2017) Synthesis and evaluation of novel antifungal agents targeted to the plasma membrane H[+]-ATPase. British Journal of Pharmacy, 2 (2). pp. 39-40. ISSN 2058-8356

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Abstract

A library of dienones were synthesized as candidate antifungal agents. These compounds were screened against Saccharomyces cerevisiae and Candida albicans using macro-broth susceptibility assay. The dienones exhibited a broad range of inhibition against S. cerevisiae (0.2-99%) and C. albicans (0-99%). 3,5-bis(p- trifluoromethylbenzylidene)-1-methyl-piperidine-4-one was identified as the most potent inhibitor of S. cerevisiae. Whereas, the most promising inhibitor of C. albicans was 2,6-bis(pyridine-3ylmethylene)cyclohexan-1-one.

Item Type: Article
Uncontrolled Keywords: antifungal, plasma membrane H+- ATPase, dienone, N-methylpiperidin-4-one
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 17 Jul 2018 11:54
Last Modified: 17 Oct 2018 20:45
URI: http://eprints.hud.ac.uk/id/eprint/34619

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