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The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems

D'Angelo, Alessandra, Edgar, Benjamin and Antonijevic, Milan (2017) The Utilisation Of Thermal Methods For The Screening Of Three Component Co-amorphous Systems. British Journal of Pharmacy, 2 (2). pp. 23-25. ISSN 2058-8356

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Abstract

Indomethacin and piroxicam are known to become amorphous upon rapid cooling after melting. Multiple three-component co-amorphous mixtures have been produced via a melt quench method to evaluate the influence of the third component on stability and physical properties on the co-amorphous mixture of piroxicam and indomethacin. These have then been tested using thermal gravimetric analysis, differential scan calorimetry and hot stage microscopy. Results have confirmed the creation of a three-component co-amorphous system.

Item Type: Article
Uncontrolled Keywords: co-amorphous, DSC, TGA, HSM
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 17 Jul 2018 10:45
Last Modified: 17 Jul 2018 11:00
URI: http://eprints.hud.ac.uk/id/eprint/34611

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