Mazhar, Syed H. R., Ismail, Nahal E., Newton, Duncan A. G. and Chrystyn, Henry (2008) Relative lung deposition of salbutamol following inhalation from a spacer and a Sidestream jet nebulizer following an acute exacerbation. British Journal of Pharmacology, 65 (3). pp. 334-337. ISSN 0306-5251

• Studies have shown that a large volume spacer attached to a metered dose inhaler provides similar bronchodilator effects to nebulized dosing during the management of patients following an acute exacerbation.

• Due to the high doses used, these effects could be measured at the top of the dose–response relationship and the response limited due to the patient's exacerbation.

• Although clinical end-points are the gold standard to show comparability, some indication of similar lung deposition is useful to consolidate any claims

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