Search:
Computing and Library Services - delivering an inspiring information environment

Impact of processing methods on the dissolution of artemether from two non-ordered mesoporous silicas

Tahir, Hira, Shahzad, Yasser, Waters, Laura J., Hussain, Talib, Yousaf, Abid Mehmood, Mahmood, Tariq and Sheikh, Rizwan (2018) Impact of processing methods on the dissolution of artemether from two non-ordered mesoporous silicas. European Journal of Pharmaceutical Sciences, 112. pp. 139-145. ISSN 0928-0987

[img] PDF - Accepted Version
Restricted to Repository staff only until 21 November 2018.
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (896kB)

Abstract

Poor aqueous solubility is often linked with a poor dissolution rate and ultimately, limited bioavailability of pharmaceutical compounds. This study describes the application of mesoporous materials (Syloid 244 and Syloid AL1) in improving the dissolution rate of a drug with poor aqueous solubility, namely artemether, utilising different processing methods including physical mixing, co-grinding and solid dispersions prepared by solvent evaporation and the lyophilisation technique. The prepared formulations were extensively characterised for their solid-state properties and the drug release attributes were studied. Differential scanning calorimetry and X-ray diffraction confirmed conversion of crystalline artemether into a disordered and amorphous form, whilst no intermolecular interactions were detected between artemether and silica. Both silica grades enhanced the dissolution rate of artemether in comparison with drug alone, for example from 17.43% (± 0.87%) to 71.55% (± 3.57%) after 120 mins with lyophilisation and Syloid 244 at a 1:3 ratio. This enhancement was also dependant on the choice of processing method, for example, co-ground and lyophilised formulations prepared with Syloid 244 at 1:3 ratio produced the most extensive dissolution, thus endorsing the importance of materials as well as choice of formulation method.

Item Type: Article
Uncontrolled Keywords: Artemether, Amorphous, Co-grinding, Dissolution, Lyophilisation, Mesoporous silica, Solid dispersion
Subjects: R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Related URLs:
Depositing User: Sally Hughes
Date Deposited: 06 Dec 2017 15:34
Last Modified: 07 Dec 2017 07:52
URI: http://eprints.hud.ac.uk/id/eprint/34061

Downloads

Downloads per month over past year

Repository Staff Only: item control page

View Item View Item

University of Huddersfield, Queensgate, Huddersfield, HD1 3DH Copyright and Disclaimer All rights reserved ©