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Biorelevant drug release of Metformin dosage forms using complementary in vitro tools

Box, Karl, O'Dwyer, Patrick and Watson, Hayley (2017) Biorelevant drug release of Metformin dosage forms using complementary in vitro tools. British Journal of Pharmacy, 2 (2). ISSN 2058-8356

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Abstract

Drug release from immediate release (IR) and extended release (ER) metformin
products was investigated using the Dow Chemical Company’s FloVitroTM
biorelevant dissolution instrument. This was complemented by using the Sirius SDi2
(Surface Dissolution Imaging) platform to investigate mechanistic differences
accounting for drug release. Level A IVIVC was demonstrated for metformin IR
dosage forms, using FloVitroTM, whilst ER tablets demonstrated lower Cmax and
Tmax using the same method. The SDi2 showed disintegration as the main release
mechanism for IR tablets, whilst swelling and drug diffusion was observed for ER
tablets. FloVitroTM and SDi2 technologies can be used to compare behaviour of
formulations during dosage form selection

Item Type: Article
Uncontrolled Keywords: Level-A IVIVC, biorelevant dissolution, surface dissolution imaging, IR/ER dosage forms, pharmacy, medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Schools: School of Applied Sciences
Depositing User: Megan Taylor
Date Deposited: 04 Dec 2017 14:35
Last Modified: 04 Dec 2017 14:35
URI: http://eprints.hud.ac.uk/id/eprint/34051

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